Herein we outline a plausible proteome, encoded by assuming a primeval RNY genetic code. We unveil the primeval phenotype by using only the RNA genotype; it means that we recovered the most ancestral proteome, mostly made of the 8 amino acids encoded by RNY triplets. By looking at those fragments, it is noticeable that they are positioned, not at catalytic sites, but in the cofactor binding sites. It implies that the stabilization of a molecule appeared long before its catalytic activity, and therefore the Ur-proteome comprised a set of proteins modules that corresponded to Cofactor Stabilizing Binding Sites (CSBSs), which we call the primitive bindome. With our method, we reconstructed the structures of the "first protein modules" that Sobolevsky and Trifonov (2006) found by using only RMSD. We also examine the probable cofactors that bound to them. We discuss the notion of CSBSs as the first proteins modules in progenotes in the context of several proposals about the primitive forms of life.

中文翻译：

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乌尔蛋白质组的提案。


在此，我们概述了一个合理的蛋白质组，通过假设原始 RNY 遗传密码进行编码。我们仅使用 RNA 基因型揭示了原始表型；这意味着我们恢复了最古老的蛋白质组，主要由 RNY 三联体编码的 8 个氨基酸组成。通过观察这些片段，可以注意到它们的位置不是在催化位点，而是在辅因子结合位点。这意味着分子的稳定性早在其催化活性之前就出现了，因此Ur-蛋白质组包含一组与辅因子稳定结合位点（CSBS）相对应的蛋白质模块，我们称之为原始结合组。通过我们的方法，我们仅使用 RMSD 重建了 Sobolevsky 和 ​​Trifonov (2006) 发现的“第一个蛋白质模块”的结构。我们还检查了与它们结合的可能的辅助因子。我们在有关原始生命形式的几个提议的背景下讨论了 CSBS 作为后代中第一个蛋白质模块的概念。