Previously, we showed that oral application of the environmental pollutant dibenzo[a,l]pyrene (DB[a,l]P) induces oral tumors in mice. Thus, in the present investigation we examined the effect of alcohol on DB[a,l]P-induced DNA damage and immune regulation; we showed that alcohol (6.4% v/v in the diet, 35% of Calories) significantly enhanced the levels of (-)-anti-trans-DB[a,l]P-dA while decreased the levels of GSH in the mouse oral tissues. Analysis of RNA expression revealed that DB[a,l]P alone upregulates inflammatory genes while alcohol suppresses several markers of immune surveillance. Collectively, these results suggest that alcohol may enhance oral carcinogenesis induced by DB[a,l]P.

中文翻译：

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长期饮酒对环境污染的小鼠口腔组织中二苯并[a，l] DNA诱导的DNA损伤和免疫调节的影响。

以前，我们表明口服环境污染物二苯并[a，l] py（DB [a，l] P）会诱发小鼠口腔肿瘤。因此，在本研究中，我们研究了酒精对DB [a，l] P诱导的DNA损伤和免疫调节的影响。我们发现酒精（饮食中v / v为6.4％，卡路里的35％）显着提高了（-）-反-反-DB [a，l] P-dA的水平，同时降低了小鼠GSH的水平口腔组织。RNA表达的分析表明，单独的DB [a，l] P会上调炎症基因，而酒精会抑制免疫监视的几个标记。总体而言，这些结果表明，酒精可能会增强DB [a，l] P诱导的口腔癌发生。