Objective: Insulin resistance (IR) plays an important role in the development of many diseases, such as diabetes mellitus. Therefore, the aim of the present study was to evaluate the effects of the extracts from fruits native to Brazil on metabolic parameters and hepatic oxidative markers in an animal model of insulin resistance induced by dexamethasone (DEX).

Methods: Wistar rats received water or extracts of Eugenia uniflora or Psidium cattleianum, once a day for 21 days. For the last 5 days, the rats received an intraperitoneal injection of saline or DEX.

Results: DEX caused a reduction in body weight gain and relative pancreatic weight, as well as glucose intolerance, and an increase in serum glucose and triacylglycerol levels. The extracts were found to prevent hyperglycemia and hypertriglyceridemia. DEX caused an increase in the levels of thiobarbituric acid-reactive substances and reactive oxygen species production in the liver of rats, and both extracts prevented these changes. In addition, hepatic glutathione peroxidase activity was reduced by DEX. However, total thiol content and activities of catalase, superoxide dismutase, and delta-aminolevulinate dehydratase were not altered in any of the tested groups.

Conclusion: Fruit extracts of E. uniflora and P. cattleianum exhibited considerable antihyperglycemic, antidyslipidemic, and antioxidant effects, and may be useful in the therapeutic management of alterations due to IR.

目的：胰岛素抵抗（IR）在许多疾病（例如糖尿病）的发生中起着重要作用。因此，本研究的目的是在巴西地塞米松（DEX）诱导的胰岛素抵抗动物模型中，评估巴西原生水果提取物对代谢参数和肝氧化标记的影响。

方法： Wistar大鼠收到水或提取物尼娅叶草或番石榴cattleianum，一旦21天。在最后5天，大鼠接受腹膜内注射盐水或DEX。

结果： DEX导致体重增加和相对胰腺重量减少，以及葡萄糖耐量下降，血清葡萄糖和三酰基甘油水平升高。发现提取物可预防高血糖症和高甘油三酸酯血症。DEX引起了大鼠肝脏中硫代巴比妥酸反应性物质的含量增加以及活性氧的产生，两种提取物均阻止了这些变化。另外，DEX降低了肝谷胱甘肽过氧化物酶的活性。但是，总的巯基含量和过氧化氢酶，超氧化物歧化酶和δ-氨基乙酰丙酸酯脱水酶的活性在任何测试组中均未改变。

结论：独角莲和山茱。的果实提取物具有显着的降血糖，抗血脂异常和抗氧化作用，可用于治疗因IR引起的改变。