当前位置: X-MOL 学术GeoHealth › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Role of Iraqi Dust in Inducing Lung Injury in United States Soldiers-An Interdisciplinary Study.
GeoHealth ( IF 4.3 ) Pub Date : 2017-07-31 , DOI: 10.1002/2017gh000071
Andrea D Harrington 1, 2, 3 , Millicent P Schmidt 2 , Anthony M Szema 4, 5 , Karen Galdanes 3 , Stella E Tsirka 6 , Terry Gordon 3 , Martin A A Schoonen 2, 7
Affiliation  

United States soldiers are returning from the Greater Middle East with respiratory illnesses ranging from new onset asthma to constrictive bronchiolitis. The etiologies of the diseases are unknown. A study was conducted to determine the possible role of local mineral dust in the development of abnormal respiratory illnesses in soldiers during and after deployment in Iraq. A dust sample obtained in proximity to a burn pit in Camp Victory, Iraq (Camp Victory dust) was characterized both chemically and mineralogically. For comparison, a dust sample from Fort Irwin, California (Fort Irwin dust) was also collected. The ability of the dust samples to generate reactive oxygen species (ROS) was quantified, as well as their ability to generate an inflammatory stress response (ISR) in human lung epithelial cells. Both samples are composed of common silicate and carbonate minerals and contain heavy metals with concentration ranges expected for mineral dust. The ISR generated by each sample was within the range of inert material with the minimal stress generated associated with the carbonate phases. The findings based on this one sample suggest that the origin of the disease is not driven by the particles ability to generate ROS. However, it is likely that particle overload and associated complications, or endotoxin contributes extensively to pathogenesis.

中文翻译:

伊拉克粉尘在美国士兵中诱发肺损伤中的作用-跨学科研究。

美国士兵从大中东地区返回,呼吸系统疾病从新发哮喘到缩窄性细支气管炎。疾病的病因未知。进行了一项研究,以确定在伊拉克部署期间和部署之后,当地矿物粉尘在士兵异常呼吸系统疾病发展中的可能作用。从化学和矿物学上对伊拉克胜利胜利营燃烧坑附近获得的粉尘样品(胜利粉尘)进行了表征。为了比较,还收集了来自加利福尼亚州欧文堡的灰尘样品(欧文堡灰尘)。定量了灰尘样品产生活性氧(ROS)的能力,以及它们在人肺上皮细胞中产生炎性应激反应(ISR)的能力。两种样品均由普通的硅酸盐和碳酸盐矿物组成,并含有重金属,其浓度范围预计为矿物粉尘。每个样品产生的ISR在惰性材料的范围内,与碳酸盐相相关的应力最小。基于这一样品的发现表明,疾病的起源不是由产生ROS的颗粒能力驱动的。但是,颗粒超载和相关并发症或内毒素可能在发病机理中广泛起作用。基于这一样品的发现表明,疾病的起源不是由产生ROS的颗粒能力驱动的。但是,颗粒超载和相关并发症或内毒素可能在发病机理中广泛起作用。基于这一样品的发现表明,疾病的起源不是由产生ROS的颗粒能力驱动的。但是,颗粒超载和相关并发症或内毒素可能在发病机理中广泛起作用。
更新日期:2017-07-31
down
wechat
bug