Women with preexisting or gestational diabetes mellitus have an increased risk for developing preeclampsia. Diabetes and pregnancy are both characterized by very high prorenin levels and renin-angiotensin system activation. Prorenin bound to the (pro)renin receptor has enzymatic activity. We hypothesized that soluble (pro)renin receptor levels are elevated in high-risk pregnancies. Third trimester maternal blood samples from complicated pregnancies (n = 165), (preeclampsia [n = 76], diabetes mellitus [type I diabetes, n = 35; type II diabetes, n = 11; gestational diabetes mellitus, n = 43]), and healthy pregnancies (n = 49) were analyzed for prorenin, renin, and soluble (pro)renin receptor. There were no significant differences in prorenin or renin levels between the study groups in a multivariate model. In the group of women with gestational diabetes, soluble (pro)renin receptor concentrations were significantly higher compared with healthy pregnancies or preeclampsia. Soluble (pro)renin receptor did not correlate with renin or prorenin levels for any of the study groups. Our results show that soluble (pro)renin receptor is dysregulated in pregnancies affected by diabetes mellitus, but not in preeclampsia. Alterations in circulating soluble (pro)renin receptor are unrelated to renin/prorenin in pregnancy, but may be of pathophysiological relevance in diabetic pregnancies in a renin-angiotensin system-independent manner.

中文翻译：

---

子痫前期和糖尿病妊娠中的可溶性（原）肾素受体。

患有先前或妊娠糖尿病的妇女患先兆子痫的风险增加。糖尿病和妊娠均以非常高的原肾素水平和肾素-血管紧张素系统激活为特征。与（肾素原）受体结合的肾素原具有酶活性。我们假设在高危妊娠中可溶性（原）肾素受体水平升高。复杂妊娠的孕中期孕妇血液样本（n = 165），（先兆子痫[n = 76]，糖尿病[I型糖尿病，n = 35； II型糖尿病，n = 11；妊娠糖尿病，n = 43]） ，并分析了健康孕妇（n = 49）的肾素，肾素和可溶性（肾素）受体。在多变量模型中，研究组之间的肾素或肾素水平无显着差异。与健康的怀孕或先兆子痫相比，妊娠糖尿病妇女组中的可溶性（原）肾素受体浓度明显更高。在任何研究组中，可溶性（肾素原）受体与肾素或肾素原水平均不相关。我们的结果表明，在受糖尿病影响的孕妇中可溶性（肾素）受体的表达失调，但在子痫前期中却没有。循环中可溶性（原）肾素受体的改变与妊娠期的肾素/肾上腺素无关，但在糖尿病妊娠中可能以与肾素-血管紧张素系统无关的方式与病理生理相关。我们的结果表明，在受糖尿病影响的孕妇中可溶性（肾素）受体的表达失调，但在子痫前期中却没有。循环中可溶性（原）肾素受体的改变与妊娠期的肾素/肾上腺素无关，但在糖尿病妊娠中可能以与肾素-血管紧张素系统无关的方式与病理生理相关。我们的结果表明，在受糖尿病影响的孕妇中可溶性（肾素）受体的表达失调，但在子痫前期中却没有。循环中可溶性（原）肾素受体的改变与妊娠期的肾素/肾上腺素无关，但在糖尿病妊娠中可能以与肾素-血管紧张素系统无关的方式与病理生理相关。