Hand-held optical coherence tomography (OCT) imaging probes offer flexibility to image sites that are otherwise challenging to access. While the majority of hand-held imaging probes utilize galvanometer- or MEMS-scanning mirrors to transversely scan the imaging beam, these probes are commonly limited to lateral fields-of-view (FOV) of only a few millimeters. The use of a freehand manually scanned probe can significantly increase the lateral FOV. However, using the traditional fixed-rate triggering scheme for data acquisition in a manually scanned probe results in imaging artifacts due to variations in the scan velocity of the imaging probe. These artifacts result in a structurally inaccurate image of the sample. In this paper, we present a sensor-based manual scanning technique for OCT imaging, where real-time feedback from an optical motion sensor is used to trigger data acquisition. This technique is able to circumvent the problem of motion artifacts during manual scanning by adaptively altering the trigger rate based on the instantaneous scan velocity, enabling OCT imaging over a large lateral FOV. The feasibility of the proposed technique is demonstrated by imaging several biological and nonbiological samples.

中文翻译：

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基于传感器的手动扫描手持式光学相干断层扫描成像技术。

手持式光学相干断层扫描（OCT）成像探头可为难以访问的成像部位提供灵活性。尽管大多数手持式成像探头都使用检流计或MEMS扫描镜横向扫描成像光束，但这些探头通常仅限于只有几毫米的侧向视场（FOV）。使用徒手手动扫描的探头会显着增加侧面FOV。然而，由于成像探针的扫描速度的变化，使用传统的固定速率触发方案在手动扫描的探针中进行数据采集会导致成像伪影。这些伪像会导致样品的结构不准确。在本文中，我们提出了一种基于传感器的OCT成像手动扫描技术，来自光学运动传感器的实时反馈用于触发数据采集。通过基于瞬时扫描速度自适应地更改触发速率，该技术能够在手动扫描过程中规避运动伪影的问题，从而能够在较大的横向FOV上进行OCT成像。通过对几种生物和非生物样品进行成像证明了所提出技术的可行性。