Mesenchymal stromal cells (MSCs) possess great therapeutic advantages due to their ability to produce a diverse array of trophic/growth factors related to cytoprotection and immunoregulation. MSC activation via specific receptors is a crucial event for these cells to exert their immunosuppressive response. The aryl-hydrocarbon receptor (AhR) is a sensitive molecule for external signals and it is expressed in MSCs and, upon positive activation, may potentially regulate the MSC-associated immunomodulatory function. Consequently, signalling pathways linked to AhR activation can elucidate some of the molecular cascades involved in MSC-mediated immunosuppression. In this minireview, we have noted some important findings concerning MSC regulation via AhR, highlighting that its activation is associated with improvement in migration and immunoregulation, as well as an increase in pro-regenerative potential. Thus, AhR-mediated MSC activation can contribute to new perspectives on MSC-based therapies, particularly those directed at immune-associated disorders.

中文翻译：

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芳烃受体在间充质基质细胞活化中的作用：综述。

间充质基质细胞（MSC）具有产生大量与细胞保护和免疫调节有关的营养/生长因子的能力，因此具有极大的治疗优势。通过特异性受体的MSC激活是这些细胞发挥其免疫抑制反应的关键事件。芳基烃受体（AhR）是外部信号的敏感分子，它在MSC中表达，并且在积极激活后可能会调节MSC相关的免疫调节功能。因此，与AhR激活相关的信号通路可以阐明与MSC介导的免疫抑制有关的某些分子级联反应。在这份小型回顾中，我们注意到了一些有关通过AhR，强调其激活与迁移和免疫调节的改善以及促再生潜能的提高有关。因此，AhR介导的MSC激活可以为基于MSC的疗法，特别是针对免疫相关疾病的疗法提供新的见解。