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Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition.
Nanoscale Horizons ( IF 9.7 ) Pub Date : 2017-10-11 , DOI: 10.1039/c6nh00202a
Sangho Won 1 , Sarah-Jane Richards 1 , Marc Walker 2 , Matthew I Gibson 1, 3
Affiliation  

Nature dynamically controls carbohydrate expression on cells rather than static presentation. Here we report synthetic glycosylated nanoparticles that contain polymeric 'gates' to enable external control (via temperature changes) of glycan surface expression, as an alternative to enzymatic control in nature. This approach offers a new dynamic multivalent scaffold for glycan recognition.

中文翻译:

纳米颗粒表面上外部可控的聚糖呈现以调节凝集素识别。

大自然动态控制细胞上的碳水化合物表达,而不是静态呈现。在这里,我们报告了合成糖基化纳米粒子,其中包含聚合物“门”,以实现对聚糖表面表达的外部控制(通过温度变化),作为自然界中酶促控制的替代方案。这种方法为聚糖识别提供了一种新的动态多价支架。
更新日期:2016-12-14
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