The functions of the lower urinary tract (LUT), such as voiding and storing urine, are dependent on complex central neural networks located in the brain, spinal cord, and peripheral ganglia. Thus, the functions of the LUT are susceptible to various neurologic disorders including spinal cord injury (SCI). SCI at the cervical or thoracic levels disrupts voluntary control of voiding and the normal reflex pathways coordinating bladder and sphincter functions. In this context, it is noteworthy that α1-adrenoceptor blockers have been reported to relieve voiding symptoms and storage symptoms in elderly men with benign prostatic hyperplasia (BPH). Tamsulosin, an α1-adrenoceptor blocker, is also considered the most effective regimen for patients with LUT symptoms such as BPH and overactive bladder (OAB).

中文翻译：

---

脊髓损伤后α1肾上腺素拮抗剂坦索罗辛对神经源性膀胱的传入途径介导作用。

下尿路（LUT）的功能（如排尿和储存尿液）取决于位于大脑，脊髓和周围神经节中的复杂中枢神经网络。因此，LUT的功能易受各种神经系统疾病的影响，包括脊髓损伤（SCI）。颈或胸水平的脊髓损伤会破坏排尿的自愿控制以及协调膀胱和括约肌功能的正常反射途径。在这种情况下，值得注意的是，据报道，α1-肾上腺素受体阻滞剂可缓解前列腺增生（BPH）老年男性的排尿症状和储存症状。坦索罗辛（α1肾上腺素受体阻滞剂）也被认为是LUT症状如BPH和膀胱过度活动症（OAB）患者最有效的治疗方案。