Patch grafts are widely used in various kind of vascular surgeries such as detect repair or dilation of vascular stenosis. Expanded polytetrafluoroethylene (ePTFE) patches are flexible and handle well, but have shown problems with calcification as they are non-bioabsorbable and therefore permanently remain in the body. It is important to develop an alternative biocompatible patch. Silk fibroin (SF) was developed as a biocompatible material, but it lacks of the elasticity required for surgery as a patch. Polyurethane (PU) is also a well-known elastomer so this study focused on the SF and the PU blend materials with a weight ratio of 5:5 (SF/PU). To evaluate the SF/PU patch, the patches were implanted into the abdominal aortas of rats, using the ePTFE patch in the control group. Because it was more flexible the SF/PU patch was easier to implant than the ePTFE patch. At 1 week after implantation, the SF/PU patch had been infiltrated with cells and collagen fiber. The ePTFE control patch did not accumulate collagen fiber until 3 months and calcification occurred at 4 weeks. The SF/PU patch did not present any signs of calcification for 3 months. This study addressed the problems associated with using SF in isolation and showed that the SF/PU patch can be considered as a useful alternative to the ePTFE to overcome the problem of calcification.

贴片移植物广泛用于各种血管外科手术中，例如检测血管狭窄的修复或扩张。膨胀的聚四氟乙烯（ePTFE）贴片具有柔韧性和良好的处理能力，但由于其不可生物吸收，因此永久留在体内，因此显示出钙化问题。开发替代的生物相容性贴剂很重要。丝素蛋白（SF）是作为一种生物相容性材料开发的，但它缺乏作为贴片的手术所需的弹性。聚氨酯（PU）也是一种众所周知的弹性体，因此本研究集中于重量比为5：5（SF / PU）的SF和PU共混材料。为了评估SF / PU贴剂，使用对照组中的ePTFE贴剂将贴剂植入大鼠的腹主动脉中。由于SF / PU贴片比ePTFE贴片更柔软，因此更易于植入。植入后1周，SF / PU贴片已被细胞和胶原纤维浸润。直到3个月，ePTFE对照贴片才积聚胶原纤维，并且在4周时发生钙化。SF / PU贴剂在3个月内没有任何钙化迹象。这项研究解决了与隔离使用SF有关的问题，并表明SF / PU贴片可被认为是ePTFE克服钙化问题的有用替代品。SF / PU贴剂在3个月内没有任何钙化迹象。这项研究解决了与隔离使用SF有关的问题，并表明SF / PU贴片可被认为是ePTFE克服钙化问题的有用替代品。SF / PU贴剂在3个月内没有任何钙化迹象。这项研究解决了与隔离使用SF有关的问题，并表明SF / PU贴片可被认为是ePTFE克服钙化问题的有用替代品。