Catecholamines play a major role in atherothrombotic mechanisms in essential hypertension. Alpha2B-adrenergic receptors (α2B-ARs) are implicated in the pathophysiology of platelet aggregation. In this study, we evaluated platelet α2B-AR gene expression levels in patients with well-controlled essential hypertension compared with normal individuals and investigated their association with increased arterial stiffness. Fifty-nine patients with well-controlled essential hypertension (34 men, mean age 65 ± 9 years) and 26 normotensives (19 men, mean age 64 ± 8 years) were included in the study. For each patient, carotid-femoral pulse wave velocity (PWV) and carotid-radial PWV were evaluated. In addition, blood samples were obtained and platelets were isolated. The α2B-AR gene expression levels in platelets were examined by real-time polymerase chain reaction for each participant. Well-controlled hypertensive patients showed significantly higher gene expression levels of α2B-Rs in platelets compared with normotensives (34.7 ± 29.5 vs 17.6 ± 12.5, respectively, P = .005). Interestingly, we found that carotid-femoral PWV and carotid-radial PWV were positively correlated with platelet α2B-R gene expression levels (r = 0.59, P < .001, and r = 0.39, P = .002, respectively).Platelet α2B-R gene expression levels are increased in patients with well-controlled essential hypertension compared with normotensives and are correlated with increased PWV in those patients. Our data indicate an association of arterial stiffness and platelet α2B-Rs gene expression and indicate the need for further research.

中文翻译：

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在控制良好的高血压中血小板α2B-肾上腺素能受体基因表达增加：动脉僵硬的影响。

儿茶酚胺在原发性高血压的动脉粥样硬化形成机制中起主要作用。α2B-肾上腺素能受体（α2B-ARs）与血小板聚集的病理生理有关。在这项研究中，我们评估了与正常个体相比，控制良好的原发性高血压患者血小板α2B-AR基因表达水平，并研究了它们与动脉僵硬度增加的关系。本研究纳入了59例控制良好的原发性高血压患者（34名男性，平均年龄65±9岁）和26例正常血压（19名男性，平均年龄64±8岁）。对于每位患者，评估其颈股脉搏波速度（PWV）和颈动脉radi动脉PWV。另外，获得血液样品并分离血小板。通过实时聚合酶链反应检查每个参与者的血小板中α2B-AR基因表达水平。对照良好的高血压患者与正常血压相比，血小板中的α2B-Rs基因表达水平显着更高（分别为34.7±29.5和17.6±12.5，P = .005）。有趣的是，我们发现颈股动脉PWV和颈动脉-动脉PWV与血小板α2B-R基因表达水平呈正相关（分别为r = 0.59，P <.001和r = 0.39，P = .002）。与正常血压相比，控制良好的原发性高血压患者的-R基因表达水平升高，并且与这些患者的PWV升高相关。我们的数据表明动脉僵硬度和血小板α2B-Rs基因表达之间存在关联，并表明需要进一步研究。