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Identification of sialyl oligosaccharides including an oligosaccharide nucleotide in colostrum of an addax (Addax nasomaculatus) (Subfamily Antelopinae).
Animal Science Journal ( IF 1.7 ) Pub Date : 2017-09-08 , DOI: 10.1111/asj.12899
Khuukhenbaatar Ganzorig 1 , Takuya Asakawa 2 , Masashi Sasaki 1 , Tadao Saito 3 , Isao Suzuki 2 , Kenji Fukuda 1 , Tadasu Urashima 1
Affiliation  

Mammalian milk/colostrum usually contains milk oligosaccharides along with the predominant lactose. Although milk oligosaccharides of a variety of Bovidae species including cow, sheep and goat have been characterized, those of the addax, an Antelopinae species of the Bovidae, have not as yet been clarified. In this study, several sialyl oligosaccharides were purified from a sample of addax colostrum and characterized as follows: Neu5Ac(α2-8)Neu5Ac(α2-3)Gal(β1-4)Glc, Neu5Gc(α2-8)Neu5Gc(α2-3)Gal(β1-4)Glc, Neu5Ac(α2-3)Gal(β1-4)Glc, Neu5Ac(α2-6)Gal(β1-4)GlcNAc, Neu5Gc(α2-3)Gal(β1-4)Glc, Neu5Gc(α2-6)Gal(β1-4)Glc, Neu5Gc(α2-6)Gal(β1-4)GlcNAc. In addition, an oligosaccharide nucleotide Neu5Gc(α2-6)Gal(β1-4)GlcNAcα1-UDP was characterized. Molecular species of a variety of sialyl oligosaccharides found in milk and colostrum of these Bovidae were compared.

中文翻译:

鉴定唾液酸(Addax nasomaculatus)(亚科Antelopinae)初乳中的唾液酸寡糖,包括寡糖核苷酸。

哺乳动物的牛奶/初乳通常含有牛奶低聚糖以及主要的乳糖。尽管已经鉴定了包括牛,羊和山羊在内的各种牛科动物的乳寡糖,但尚未弄清牛科动物的羚羊科的addax的那些。在这项研究中,从Addax初乳样品中纯化了几种唾液酸寡糖,其特征如下:Neu5Ac(α2-8)Neu5Ac(α2-3)Gal(β1-4)Glc,Neu5Gc(α2-8)Neu5Gc(α2- 3)Gal(β1-4)Glc,Neu5Ac(α2-3)Gal(β1-4)Glc,Neu5Ac(α2-6)Gal(β1-4)GlcNAc,Neu5Gc(α2-3)Gal(β1-4) Glc,Neu5Gc(α2-6)Gal(β1-4)Glc,Neu5Gc(α2-6)Gal(β1-4)GlcNAc。另外,表征了寡核苷酸Neu5Gc(α2-6)Gal(β1-4)GlcNAcα1-UDP。比较了这些牛科动物的牛奶和初乳中发现的各种唾液酸寡糖的分子种类。
更新日期:2019-11-01
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