Global crop production is highly threatened due to pathogen invasion. The huge quantity of pesticides application, although harmful to the environment and human health, is carried out to prevent the crop losses worldwide, every year. Therefore, understanding the molecular mechanisms of pathogenicity and plant resistance against pathogen is important. The resistance against pathogens is regulated by three important phytohormones viz. salicylic acid (SA), jasmonic acid (JA) and ethylene (ET). Here we review possible role of CRISPR technology to understand the plant pathogenicity by mutating genes responsible for pathogen invasion or up-regulating the phytohormones genes or resistant genes. Thus hormone biosynthesis genes, receptor and feeding genes of pathogens could be important targets for modifications using CRISPR/Cas9 following multiplexing tool box strategy in order to edit multiple genes simultaneously to produce super plants. Here we put forward our idea thatthe genes would be either mutated in case of plant receptor protein targets of pathogens or up-regulation of resistant genes or hormone biosynthesis genes will be better choice for resistance against pathogens.

中文翻译：

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CRISPR/Cas9 介导的植物对病原体的免疫。

由于病原体入侵，全球作物生产受到高度威胁。每年大量使用杀虫剂，虽然对环境和人类健康有害，但为了防止世界范围内的作物损失而进行。因此，了解致病性和植物对病原体抗性的分子机制非常重要。对病原体的抵抗力由三种重要的植物激素调节，即。水杨酸 (SA)、茉莉酸 (JA) 和乙烯 (ET)。在这里，我们回顾了 CRISPR 技术通过突变导致病原体入侵的基因或上调植物激素基因或抗性基因来了解植物致病性的可能作用。因此激素生物合成基因，病原体的受体和摄食基因可能是使用 CRISPR/Cas9 按照多路复用工具箱策略进行修饰的重要目标，以便同时编辑多个基因以产生超级植物。在这里，我们提出了我们的想法，即基因在植物受体蛋白靶标的病原体的情况下发生突变，或者抗性基因或激素生物合成基因的上调将是抵抗病原体的更好选择。