Objective: The objective of the present study was to examine selected parameters of the blood redox system in elderly patients with hypertension.examine selected parameters of the blood redox system in elderly patients with hypertension. Methods: We analyzed differences in redox-associated molecules and enzymes among elderly hypertensive subjects (age above 65 years, n = 49) and two groups of normotensive subjects (<65 years old – Control group I; n = 27, and >65 – Control group II; n = 30). Results: Decreased activity of antioxidant enzymes, increased lipid peroxidation and reduced production of nitric oxide were observed in hypertensive subjects, compared to healthy younger controls, or those of the same age. In healthy controls, an age-related decrease in the production of nitric oxide and the activities of SOD-1 and GPx-1 was also evident. The pathology of hypertension was characterised by further, significant decreases in the values of these parameters. When the subgroups of females and males were compared to their respective controls, a compromised redox balance was observed that was more evident in female hypertensives. Discussion: Hypertension in elderly patients is accompanied by changes in biomarkers of antioxidant status and lipid peroxidation status, which significantly differ from those observed in healthy ageing subjects. Our study also suggests that the relationship of gender and changes in redox balance with regard to hypertension should be further explored.

目的：本研究的目的是检测老年高血压患者血液氧化还原系统的选定参数。检测老年高血压患者血液氧化还原系统的选定参数。方法：我们分析了老年高血压受试者（65 岁以上，n  = 49）和两组血压正常受试者（<65 岁 – 对照组 I；n  = 27，和 >65 –对照组 II；n  = 30)。结果：与健康的年轻对照组或同龄人相比，在高血压受试者中观察到抗氧化酶活性降低、脂质过氧化作用增加和一氧化氮产生减少。在健康对照组中，与年龄相关的一氧化氮生成以及 SOD-1 和 GPx-1 活性的下降也很明显。高血压的病理特征在于这些参数值的进一步显着降低。当将女性和男性的亚组与其各自的对照组进行比较时，观察到氧化还原平衡受损，这在女性高血压患者中更为明显。讨论：老年患者的高血压伴随着抗氧化状态和脂质过氧化状态的生物标志物的变化，这与在健康老年受试者中观察到的显着不同。我们的研究还表明，应进一步探讨性别与氧化还原平衡变化与高血压之间的关系。