Specific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advantages and clinical benefits of FGS over other conventional medical imaging modalities, such as its safety, effectiveness, and suitability for real-time imaging in the operating room. Recent advancements in contrast agents and intraoperative fluorescence imaging devices have led to a greater potential for intraoperative fluorescence imaging in clinical applications. Photodynamic therapy (PDT) is an alternative modality to treat tumors, which uses a light-sensitive drug (photosensitizers) and special light to destroy the targeted tissues. In this review, we discuss the fluorescent contrast agents, some newly developed imaging devices, and the successful clinical application of FGS. Additionally, we present the combined strategy of FGS with PDT to further improve the therapeutic effect for patients with cancer. Taken together, this review provides a unique perspective and summarization of FGS.

中文翻译：

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荧光引导手术与光动力疗法相结合治疗癌症。


手术期间需要对身体部位进行具体的可视化。荧光引导手术（FGS）使用荧光造影剂进行体内肿瘤成像，以检测和识别恶性组织和正常组织。与其他传统医学成像方式相比，FGS 具有多种优势和临床益处，例如其安全性、有效性以及手术室实时成像的适用性。造影剂和术中荧光成像设备的最新进展使得术中荧光成像在临床应用中具有更大的潜力。光动力疗法（PDT）是治疗肿瘤的另一种方法，它使用光敏药物（光敏剂）和特殊光来破坏目标组织。在这篇综述中，我们讨论了荧光造影剂、一些新开发的成像设备以及 FGS 的成功临床应用。此外，我们提出了FGS与PDT的联合策略，以进一步提高癌症患者的治疗效果。总而言之，这篇综述提供了 FGS 的独特视角和总结。