Objectives: In congestive heart failure (CHF), men are younger, more likely to have reduced ejection fraction (HF-rEF), and to be diabetic compared to women. Despite this, sex differences in oxidative stress have yet to be explored in CHF.

Methods: Data from 67 males and 63 females hospitalized for CHF were collected. Static oxidation–reduction potential (sORP), a relative indicator of oxidative stress, and capacity ORP (icORP), a relative indicator of antioxidant capacity, were measured from plasma samples. We examined whether sex modified the relationship between ORP and hospital discharge disposition (poor outcome: death, hospice), along with other demographics, medications, and diagnostic parameters.

Results: Males with poor outcomes had higher sORP and icORP values than females (P < 0.05). For those with a good outcome, there were no differences between the sexes (P > 0.05). Males were younger and more likely to have HF-rEF and diabetes. Controlling for these variables did not account for the sex differences in ORP measures. Regardless of sex, higher creatinine was related to higher sORP and icORP, while lower magnesium and potassium were related to higher sORP and icORP, respectively.

Discussion: Increases in sORP during CHF are partially affected by sex and acute outcomes, but are also related to variables without sexual biases.

目的：在充血性心力衰竭 (CHF) 中，与女性相比，男性更年轻，射血分数降低 (HF-rEF) 的可能性更大，并且患有糖尿病。尽管如此，尚未在 CHF 中探索氧化应激的性别差异。

方法：收集了因 CHF 住院的 67 名男性和 63 名女性的数据。从血浆样品中测量静态氧化还原电位 (sORP)，一种氧化应激的相对指标，以及容量 ORP ( i cORP)，一种抗氧化能力的相对指标。我们检查了性别是否改变了 ORP 和出院处置（不良结果：死亡、临终关怀）以及其他人口统计、药物和诊断参数之间的关系。

结果：预后不良的男性sORP和i cORP值高于女性（P  <0.05）。预后较好者，两性之间无差异（P  > 0.05）。男性更年轻，更有可能患有 HF-rEF 和糖尿病。控制这些变量并没有考虑 ORP 测量的性别差异。无论性别如何，较高的肌酐与较高的 sORP 和i cORP 相关，而较低的镁和钾分别与较高的 sORP 和i cORP 相关。

讨论： CHF 期间 sORP 的增加部分受性别和急性结果的影响，但也与没有性别偏见的变量有关。