Skin is a complex organ and the largest interface of the human body exposed to numerous stress and pathogens. Skin is composed of different cell types that together perform essential functions such as pathogen sensing, barrier maintenance and immunity, at once providing the first line of defense against microbial infections and ensuring skin homeostasis. Being inoculated directly through the epidermis and the dermis during a vector blood meal, emerging Dengue, Zika andWest Nile mosquito-borne viruses lead to the initiation of the innate immune response in resident skin cells and to the activation of dendritic cells, which migrate to the draining lymph node to elicit an adaptive response. This literature review aims to describe the inflammatory response and the innate immune signalization pathways involved in human skin cells during Dengue, Zika and West Nile virus infections.

中文翻译：

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皮肤对黄病毒感染的天然免疫反应。

皮肤是复杂的器官，是人体的最大界面，暴露于多种压力和病原体中。皮肤由不同的细胞类型组成，这些细胞共同执行基本功能，例如病原体感测，屏障维持和免​​疫，可立即提供抵御微生物感染的第一道防线，并确保皮肤稳态。登革热，寨卡病毒和西尼罗河蚊子传播的新病毒直接在媒介血餐中通过表皮和真皮接种，从而导致驻在皮肤细胞中先天免疫应答的启动以及树突状细胞的激活，这些树突状细胞迁移至引流淋巴结以引起适应性反应。这篇文献综述旨在描述登革热期间人类皮肤细胞所涉及的炎症反应和先天性免疫信号传导途径，