High dietary sodium intake can lead to hypertension and increased incidence of cardiovascular disease. We sought to determine the effect of short-term dietary sodium loading on central blood pressure and arterial stiffness in young (YG; 22-40 years) and middle-aged (MA; 41-60 years) normotensive adults. YG (n = 49; age: 27 ± 1 years) and MA (n = 36; age: 52 ± 1 years) subjects were randomized, in a cross-over design, to 7 days of low-sodium (LS; 20 mmol/d) or high-sodium (HS; 300 mmol/d) diet. On the last day of each diet, central pressures, forward and reflected wave amplitudes (via radial artery applanation tonometry), and carotid-femoral pulse wave velocity were assessed. Central systolic blood pressure (cSBP) was greater after HS in both YG (LS: 96 ± 1 vs. HS: 99 ± 1 mm Hg; P = .012) and MA (LS: 106 ± 2 vs. HS: 115 ± 3 mm Hg; P < .001). However, the increase in cSBP was greater in MA (YG: 4 ± 1 vs. MA: 9 ± 2; P = .02). In MA subjects, HS elicited greater forward (LS: 25 ± 1 vs. HS: 29 ± 1 mm Hg; P < .001) and reflected (LS: 19 ± 1 vs. HS: 23 ± 1 mm Hg; P < .001) wave amplitudes. Carotid-femoral pulse wave velocity was also greater in MA on HS but after adjustment for mean arterial pressure, the difference was no longer significant. Our data indicate that HS intake leads to a greater increase in cSBP in MA adults, which may be the result of increased forward and reflected wave amplitudes.

中文翻译：

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年轻人和中年人对饮食中钠的中央收缩压和主动脉僵硬反应。

饮食中钠的高摄入量可能导致高血压和心血管疾病的增加。我们试图确定短期饮食中钠的摄入量对年轻（YG； 22-40岁）和中年（MA； 41-60岁）成年人的中心血压和动脉僵硬的影响。YG（n = 49；年龄：27±1岁）和MA（n = 36；年龄：52±1岁）受试者以交叉设计随机分为7天低钠（LS; 20 mmol / d）或高钠（HS; 300 mmol / d）饮食。在每种饮食的最后一天，评估中心压力，前向和反射波幅度（通过radial动脉扁平眼压计）和颈股动脉脉搏波速度。HS后YG（LS：96±1 vs. HS：99±1 mm Hg; P = .012）和MA（LS：106±2 vs. HS：115±3）的中心收缩压（cSBP）均较高毫米汞柱; P <0.001）。然而，MA中cSBP的增加更大（YG：4±1 vs. MA：9±2； P = .02）。在MA受试者中，HS引起更大的向前运动（LS：25±1 vs. HS：29±1 mm Hg； P <.001）并反射（LS：19±1 vs. HS：23±1 mm Hg； P <。 001）波幅。在HS的MA中，颈股脉搏波速度也较大，但在调整平均动脉压后，差异不再显着。我们的数据表明，HS摄入量会导致MA成人cSBP的增加，这可能是前向和反射波幅度增加的结果。在HS的MA中，颈股脉搏波速度也较大，但在调整平均动脉压后，差异不再显着。我们的数据表明，HS摄入量会导致MA成人cSBP的增加更大，这可能是前向和反射波幅度增加的结果。在HS的MA中，颈股脉搏波速度也较大，但在调整平均动脉压后，差异不再显着。我们的数据表明，HS摄入量会导致MA成人cSBP的增加，这可能是前向和反射波幅度增加的结果。