Probiotics are defined as 'live microorganisms which when administered in adequate amounts confer a health benefit on the host'. So, to consider a microorganism as a probiotic, a demonstrable beneficial effect on the health host should be shown as well as an adequate defined safety status and the capacity to survive transit through the gastrointestinal tract and to storage conditions. In this review, we present an overview of the murine colitis models currently employed to test the beneficial effect of the probiotic strains as well as an overview of the probiotics already tested. Our aim is to highlight both the importance of the adequate selection of the animal model to test the potential probiotic strains and of the value of the knowledge generated by these in vivo tests.

中文翻译：

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使用小鼠结肠炎模型分析益生菌与宿主之间的相互作用。

益生菌被定义为“活微生物，当以足够的量给药时，可以给宿主带来健康益处”。因此，将微生物视为益生菌，应显示出对健康宿主的可证明的有益作用，以及确定的适当安全状态以及通过胃肠道和储存条件生存的能力。在这篇综述中，我们提供了目前用于测试益生菌菌株的有益效果的鼠科结肠炎模型的概述，以及已经测试过的益生菌的概述。我们的目的是强调充分选择动物模型以测试潜在益生菌菌株的重要性以及这些体内测试所产生的知识价值。