Bioimpedance measurements with the Body Composition Monitor (BCM) have been shown to improve fluid management in haemodialysis. However, there is a lack of a sufficiently robust evidence-base for use of the BCM outside of standard protocols. This study aims to characterise BCM measurement variation to allow users to make measurements and interpret the results with confidence in a range of clinical scenarios. BCM measurements were made in 48 healthy controls and in 48 stable haemodialysis patients before and immediately after dialysis. The effect of utilising alternative measurement paths was assessed using mixed effects models and the effect of measuring post-dialysis was assessed by comparing changes in BCM-measured overhydration (OH) with weight changes over dialysis. The data from healthy controls suggest that there is no difference in BCM-measured OH between all the whole-body paths other than the foot-to-foot measurement. Dialysis patients showed similar results other than having higher BCM-measured OH when measured across the site of a vascular access. There was good agreement between BCM-measured OH and change in weight, suggesting post-dialysis measurements can be utilised. These results suggest BCM protocols can be flexible regarding measurement paths and timing of measurement to ensure as many patients as possible can benefit from the technology.

中文翻译：

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身体成分监测器：用于血液透析人群常规液体管理的灵活工具

使用身体成分监测器 (BCM) 进行的生物阻抗测量已被证明可以改善血液透析中的液体管理。然而，在标准协议之外使用 BCM 缺乏足够强大的证据基础。本研究旨在表征 BCM 测量变化，以允许用户在一系列临床场景中自信地进行测量并解释结果。48 名健康对照者和 48 名稳定的血液透析患者在透析前和透析后立即进行 BCM 测量。使用混合效应模型评估了利用替代测量路径的效果，并通过比较 BCM 测量的过度水合 (OH) 的变化与透析后体重的变化来评估透析后测量的效果。来自健康对照组的数据表明，除了脚对脚测量之外，所有全身路径之间的 BCM 测量的 OH 没有差异。透析患者显示出类似的结果，除了在血管通路部位测量时 BCM 测量的 OH 更高。BCM 测量的 OH 和体重变化之间有很好的一致性，表明可以使用透析后测量。这些结果表明，BCM 协议可以灵活地考虑测量路径和测量时间，以确保尽可能多的患者可以从该技术中受益。BCM 测量的 OH 和体重变化之间有很好的一致性，表明可以使用透析后测量。这些结果表明，BCM 协议可以灵活地考虑测量路径和测量时间，以确保尽可能多的患者可以从该技术中受益。BCM 测量的 OH 和体重变化之间有很好的一致性，表明可以使用透析后测量。这些结果表明，BCM 协议可以灵活地考虑测量路径和测量时间，以确保尽可能多的患者可以从该技术中受益。