Objective: We designed this study to observe the effect of galangin on damaged mitochondria in the liver of diabetic rats.

Methods: Male albino Wistar rats were made diabetic by injecting streptozotocin (STZ) intraperitoneally (40 mg kg⁻¹ body weight (BW)). Galangin (8 mg kg⁻¹ BW) or glibenclamide (600 µg kg⁻¹ BW) was given orally daily once for 45 days to both healthy and diabetic rats.

Results: Diabetic rats showed significant (P < 0.05) increase in liver mitochondrial oxidant [Thiobarbituric acid reactive substance (TBARS)] level and a significant decrease in enzymatic [superoxide dismutase (SOD), glutathione peroxidase (GPx)] and non-enzymatic (reduced glutathione (GSH)) antioxidant levels when compared with healthy rats. The mitochondrial enzymes isocitrate dehydrogenase (ICDH), alpha-ketoglutarate dehydrogenase (α-KGDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) and mitochondrial respiratory chain enzymes NADH-dehydrogenase and Cytochrome c-oxidase were decreased significantly (P < 0.05) in diabetic rats when compared with healthy rats. A natural flavonoid galangin administered to hyperglycemia-induced rats resulted in the following findings as compared to hyperglycemia-induced control rats: the oxidant levels decreased significantly (P < 0.05); the enzymatic and non-enzymatic antioxidant levels increased significantly (P < 0.05) and the function of mitochondrial enzymes and the mitochondrial respiratory chain enzymes increased significantly (P < 0.05).

Conclusion: From the results, we conclude that galangin could maintain liver mitochondrial function in diabetic rats.

目的：本研究旨在观察高良姜精对糖尿病大鼠肝脏线粒体损伤的作用。

方法：通过腹膜内注射链脲佐菌素（STZ）（40 mg kg ^-1体重（BW））使雄性白化病Wistar大鼠成为糖尿病。健康和糖尿病大鼠每天口服高良姜精（8 mg kg ^-1 BW）或格列本脲（600 µg kg ^-1 BW）一次，持续45天。

结果：糖尿病大鼠 肝线粒体氧化剂[硫代巴比妥酸反应性物质（TBARS）]水平显着增加（P <0.05），酶促[超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPx）]和非酶促（Px 0.05）显着降低。与健康大鼠相比，降低了谷胱甘肽（GSH））的抗氧化剂水平。线粒体酶异柠檬酸脱氢酶（ICDH），α-酮戊二酸脱氢酶（α-KGDH），琥珀酸脱氢酶（SDH）和苹果酸脱氢酶（MDH）以及线粒体呼吸链酶NADH脱氢酶和细胞色素c氧化酶显着降低（P 与健康大鼠相比，糖尿病大鼠的<0.05）。与高血糖诱导的对照组大鼠相比，向高血糖诱导的大鼠施用天然类黄酮高良姜精有以下发现：氧化剂水平显着降低（P  <0.05）；酶和非酶抗氧化剂水平显着增加（P  <0.05），线粒体酶和线粒体呼吸链酶的功能显着增加（P  <0.05）。

结论：从结果可以得出结论，高良姜素可以维持糖尿病大鼠的肝线粒体功能。