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Galangin, a natural flavonoid reduces mitochondrial oxidative damage in streptozotocin-induced diabetic rats.
Redox Report ( IF 5.2 ) Pub Date : 2017-08-16 , DOI: 10.1080/13510002.2017.1365224
Amal A Aloud 1 , Chinnadurai Veeramani 2 , Chandramohan Govindasamy 2 , Mohammed A Alsaif 2 , Khalid S Al-Numair 2
Affiliation  

Objective: We designed this study to observe the effect of galangin on damaged mitochondria in the liver of diabetic rats.

Methods: Male albino Wistar rats were made diabetic by injecting streptozotocin (STZ) intraperitoneally (40 mg kg−1 body weight (BW)). Galangin (8 mg kg−1 BW) or glibenclamide (600 µg kg−1 BW) was given orally daily once for 45 days to both healthy and diabetic rats.

Results: Diabetic rats showed significant (P < 0.05) increase in liver mitochondrial oxidant [Thiobarbituric acid reactive substance (TBARS)] level and a significant decrease in enzymatic [superoxide dismutase (SOD), glutathione peroxidase (GPx)] and non-enzymatic (reduced glutathione (GSH)) antioxidant levels when compared with healthy rats. The mitochondrial enzymes isocitrate dehydrogenase (ICDH), alpha-ketoglutarate dehydrogenase (α-KGDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) and mitochondrial respiratory chain enzymes NADH-dehydrogenase and Cytochrome c-oxidase were decreased significantly (P < 0.05) in diabetic rats when compared with healthy rats. A natural flavonoid galangin administered to hyperglycemia-induced rats resulted in the following findings as compared to hyperglycemia-induced control rats: the oxidant levels decreased significantly (P < 0.05); the enzymatic and non-enzymatic antioxidant levels increased significantly (P < 0.05) and the function of mitochondrial enzymes and the mitochondrial respiratory chain enzymes increased significantly (P < 0.05).

Conclusion: From the results, we conclude that galangin could maintain liver mitochondrial function in diabetic rats.



中文翻译:

高良姜素是一种天然的类黄酮,可减少链脲佐菌素诱导的糖尿病大鼠的线粒体氧化损伤。

目的:本研究旨在观察高良姜精对糖尿病大鼠肝脏线粒体损伤的作用。

方法:通过腹膜内注射链脲佐菌素(STZ)(40 mg kg -1体重(BW))使雄性白化病Wistar大鼠成为糖尿病。健康和糖尿病大鼠每天口服高良姜精(8 mg kg -1 BW)或格列本脲(600 µg kg -1 BW)一次,持续45天。

结果:糖尿病大鼠 肝线粒体氧化剂[硫代巴比妥酸反应性物质(TBARS)]水平显着增加(P <0.05),酶促[超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GPx)]和非酶促(Px 0.05)显着降低。与健康大鼠相比,降低了谷胱甘肽(GSH))的抗氧化剂水平。线粒体酶异柠檬酸脱氢酶(ICDH),α-酮戊二酸脱氢酶(α-KGDH),琥珀酸脱氢酶(SDH)和苹果酸脱氢酶(MDH)以及线粒体呼吸链酶NADH脱氢酶和细胞色素c氧化酶显着降低(P 与健康大鼠相比,糖尿病大鼠的<0.05)。与高血糖诱导的对照组大鼠相比,向高血糖诱导的大鼠施用天然类黄酮高良姜精有以下发现:氧化剂水平显着降低(P  <0.05);酶和非酶抗氧化剂水平显着增加(P  <0.05),线粒体酶和线粒体呼吸链酶的功能显着增加(P  <0.05)。

结论:从结果可以得出结论,高良姜素可以维持糖尿病大鼠的肝线粒体功能。

更新日期:2017-08-16
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