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Strain-dependent sex differences in a long-term forced swim paradigm.
Behavioral Neuroscience ( IF 1.6 ) Pub Date : 2017-08-14 , DOI: 10.1037/bne0000215
José Colom-Lapetina 1 , Sabrina L Begley 1 , Megan E Johnson 1 , Kristina J Bean 1 , Whitney N Kuwamoto 1 , Rebecca M Shansky 1
Affiliation  

Women are twice as likely as men to suffer from trauma- and stressor-related disorders. The development of improved therapeutic interventions is contingent upon a more complete grasp of both the neural and behavioral dynamics of the stress response in females. The rodent forced swim test (FST) is a valuable animal model for exploring the neurobiological mechanisms responsible for selection of active and passive responses to inescapable stressors, but it is often neglected in 2-day FST studies is the dissociation of innate (Day 1) versus learned (Day 2) coping responses. Here, we used a modified, long-term (4-week) FST paradigm and immunohistological analysis to study the interactions of sex, strain, and housing arrangement on selection of active and passive coping strategies in Sprague Dawley (SD) and Long Evans (LE) rats. We observed significant strain × sex interactions in both forced swim sessions with respect to both passive (immobility) and active (climbing and headshakes) responses. In immobility measures, we observed stable sex differences in SD rats and a stable lack of sex differences in LE rats across tests. In addition, both SD and LE females displayed significantly more headshakes than males during Test 1 and more climbing in Test 2. Most notably, males, but not females, exhibited a cross-test increase in immobility, suggesting that males and females may engage different learning processes in a 2-day FST. These sex differences corresponded to c-fos expression in the medial prefrontal cortex (mPFC), indicating that the mPFC may contribute to sexually dimorphic behavior in the FST. (PsycINFO Database Record

中文翻译:

长期强迫游泳范例中依赖应变的性别差异。

女性患外伤和应激相关疾病的可能性是男性的两倍。改善治疗干预措施的发展取决于对女性应激反应的神经动力学和行为动力学的更完全掌握。啮齿动物强迫游泳试验(FST)是一种有价值的动物模型,用于探索负责选择对不可避免的应激源的主动和被动反应的神经生物学机制,但在为期2天的FST研究中通常忽略了先天的分离(第1天)与学习(第2天)的应对方式进行比较。在这里,我们使用改良的长期(4周)FST范例和免疫组织学分析来研究性别,劳损和住房安排在选择Sprague Dawley(SD)和Long Evans(主动和被动应对策略)时的相互作用。 LE)大鼠。在被动游泳(不动)和主动(攀爬和摇头)反应方面,我们都观察到在强迫游泳过程中都存在明显的压力×性别相互作用。在不动措施中,我们观察到SD大鼠的性别稳定,而LE大鼠的性别缺乏稳定。此外,在测试1中,SD和LE女性的摇晃次数明显多于男性,而在测试2中攀爬的次数更多。最显着的是,男性(而非女性)的交叉运动性增加,表明男性和女性的交往可能有所不同。 2天FST中的学习过程。这些性别差异对应于内侧前额叶皮层(mPFC)中的c-fos表达,表明mPFC可能有助于FST中的性二态行为。(PsycINFO数据库记录 我们观察到SD大鼠的性别差异稳定,而LE大鼠的性别差异稳定。此外,在测试1中,SD和LE女性的摇晃次数明显多于男性,而在测试2中攀爬的次数更多。最显着的是,男性(而非女性)的交叉运动性增加,表明男性和女性的交往可能有所不同。 2天FST中的学习过程。这些性别差异对应于内侧前额叶皮层(mPFC)中的c-fos表达,表明mPFC可能有助于FST中的性二态行为。(PsycINFO数据库记录 我们观察到SD大鼠的性别差异稳定,而LE大鼠的性别差异稳定。此外,在测试1中,SD和LE女性的摇晃次数明显多于男性,而在测试2中攀爬的次数更多。最显着的是,男性(而非女性)的交叉运动性增加,表明男性和女性的交往可能有所不同。 2天FST中的学习过程。这些性别差异对应于内侧前额叶皮层(mPFC)中的c-fos表达,表明mPFC可能有助于FST中的性二态行为。(PsycINFO数据库记录 表现出交叉测试的固定性增加,表明男性和女性在2天FST中可能参与不同的学习过程。这些性别差异对应于内侧前额叶皮层(mPFC)中的c-fos表达,表明mPFC可能有助于FST中的性二态行为。(PsycINFO数据库记录 表现出交叉测试的固定性增加,表明男性和女性在2天FST中可能参与不同的学习过程。这些性别差异对应于内侧前额叶皮层(mPFC)中的c-fos表达,表明mPFC可能有助于FST中的性二态行为。(PsycINFO数据库记录
更新日期:2020-08-21
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