Serotonin signaling is vital for reward processing, and hence, also for decision-making. The serotonin transporter gene linked polymorphic region (5-HTTLPR) has been connected to decision making, suggesting that short-allele carriers (s) are more risk averse than long-allele homozygotes (ll). However, previous research has not identified if this occurs because s-carriers (i) are more sensitive to the uncertainty of the outcomes or (ii) are more sensitive to the magnitude of the outcomes. This issue was disentangled using a willingness-to-pay task, where the participants evaluated prospects involving certain gains, uncertain gains, and ambiguous gains. The results clearly favored the hypothesis that s-carriers react more to the magnitude of the outcomes. Self-reported measures of everyday risk-taking behavior also favored this hypothesis. We discuss how these results are in line with recent research on the serotonergic impact on reward processing. (PsycINFO Database Record

中文翻译：

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分解5-羟色胺对风险感知的影响：5-HTTLPR的S携带者主要关注结果的大小，而不是不确定性。

5-羟色胺信号传导对于奖励处理至关重要，因此对于决策也至关重要。血清素转运蛋白基因连接的多态性区域（5-HTTLPR）已与决策相关，这表明短等位基因携带者比长等位基因纯合子（II）规避风险。但是，以前的研究尚未确定是否会发生这种情况，因为s-携带者（i）对结果的不确定性更敏感，或者（ii）对结果的大小更敏感。使用支付意愿任务可以解决此问题，在该任务中，参与者评估了涉及某些收益，不确定收益和含糊收益的前景。结果显然支持了s携带者对结果幅度反应更大的假设。自我报告的日常冒险行为的测度也支持这一假设。我们讨论了这些结果如何与有关血清素能对奖惩处理的影响的最新研究一致。（PsycINFO数据库记录