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Deciphering critical amino acid residues to modify and enhance the binding affinity of ankyrin scaffold specific to capsid protein of human immunodeficiency virus type 1.
Asian Pacific Journal of Allergy and Immunology ( IF 2.3 ) Pub Date : 2017-8-13 , DOI: 10.12932/ap-280217-0037
Somphot Saoin,Tanchanok Wisitponchai,Kannaporn Intachai,Koollawat Chupradit,Sutpirat Moonmuang,Sawitree Nangola,Kuntida Kitidee,Kanda Fanhchaksai,Vannajan Sanghiran Lee,Saw-See Hong,Pierre Boulanger,Phimonphan Chuankhayan,Chun-Jung Chen,Chatchai Tayapiwatana

AnkGAG1D4 is an artificial ankyrin repeat protein which recognizes the capsid protein (CA) of the human immunodeficiency virus type 1 (HIV-1) and exhibits the intracellular antiviral activity on the viral assembly process. Improving the binding affinity of AnkGAG1D4 would potentially enhance the AnkGAG1D4-mediated antiviral activity.

中文翻译:

解密关键氨基酸残基以修饰和增强锚蛋白支架对人免疫缺陷病毒1型衣壳蛋白特异的结合亲和力。

AnkGAG1D4是一种人工锚蛋白重复蛋白,可识别1型人类免疫缺陷病毒(HIV-1)的衣壳蛋白(CA),并在病毒装配过程中表现出细胞内抗病毒活性。改善AnkGAG1D4的结合亲和力可能会增强AnkGAG1D4介导的抗病毒活性。
更新日期:2020-08-21
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