Engineering microorganisms capable of simultaneously accumulating multiple products are economically attractive for biotechnology. Polyhydroxyalkanoates (PHA) or microbial bioplastics are promising as biodegradable plastics to address environmental concerns resulted from plastic wastes accumulation. Unfortunately, PHA production is still limited and cannot compete with the chemically synthesized plastics due to their high production cost. Efforts have been devoted to reduce PHA production cost by employing PHA co-production with other valuable chemicals. Successful co-productions of PHA have been demonstrated with amino acids, proteins, alcohols, hydrogen, biosurfactants, exopolysaccharides and several fine chemicals. The strategy allows recovering PHA from the cells and other value-added products from the no-cells broths. Numerous successful strategies have been developed for minimizing the substrate cost and improving the product yields. This paper reviews the recent strategies developed in PHA co-production with other compounds, discusses the challenges and prospective during the scale up of the co-production strategies.

中文翻译：

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与其他化学品共同生产微生物聚羟基链烷酸酯。

能够同时积累多种产物的工程微生物对生物技术具有经济吸引力。聚羟基链烷酸酯（PHA）或微生物生物塑料有望成为可生物降解的塑料，以解决塑料废物堆积造成的环境问题。不幸的是，由于PHA的生产成本高，因此PHA的生产仍然受到限制，无法与化学合成塑料竞争。通过与其他有价值的化学物质共同生产PHA，致力于降低PHA的生产成本。已证明PHA与氨基酸，蛋白质，醇，氢，生物表面活性剂，胞外多糖和多种精细化学品的成功联产。该策略允许从细胞中回收PHA，并从无细胞肉汤中回收其他增值产品。已经开发出许多成功的策略来最小化基板成本并提高产品产量。本文回顾了PHA与其他化合物联合生产中开发的最新策略，讨论了在扩大联合生产策略过程中的挑战和前景。