The unique selectivity of enzymes, along with their remarkable catalytic activity, constitute powerful tools for transforming renewable feedstock and also for adding value to an array of building blocks and monomers produced by the emerging bio-based chemistry sector. Although some relevant biotransformations run at the ton scale demonstrate the success of biocatalysis in industry, there is still a huge untapped potential of catalytic activities available for targeted valorization of new raw materials, such as waste streams and CO2. For decades, the needs of the pharmaceutical and fine chemistry sectors have driven scientific research in the field of biocatalysis. Nowadays, such consolidated advances have the potential to translate into effective innovation for the benefit of bio-based chemistry. However, the new scenario of bioeconomy requires a stringent integration between scientific advances and economics, and environmental as well as technological constraints. Computational methods and tools for effective big-data analysis are expected to boost the use of enzymes for the transformation of a new array of renewable feedstock and, ultimately, to enlarge the scope of biocatalysis.

中文翻译：

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发展生物催化以应对生物经济挑战和机遇

酶的独特选择性及其卓越的催化活性构成了转化可再生原料以及为新兴生物基化学部门生产的一系列构建块和单体增加价值的强大工具。尽管一些相关的吨级生物转化证明了生物催化在工业中的成功，但仍有巨大的未开发潜力可用于新原材料（如废物流和二氧化碳）的有针对性的价值化。几十年来，制药和精细化学领域的需求推动了生物催化领域的科学研究。如今，这种综合进步有可能转化为有益于生物化学的有效创新。然而，生物经济的新情景需要科学进步与经济、环境和技术限制之间的严格整合。用于有效大数据分析的计算方法和工具有望促进酶的使用，以转化一系列新的可再生原料，并最终扩大生物催化的范围。