Trends in Cancer ( IF 14.3 ) Pub Date : 2016-04-04 , DOI: 10.1016/j.trecan.2016.03.002 Yong Liu 1 , Chad Deisenroth 2 , Yanping Zhang 3
Ribosomal biogenesis is tightly associated with cellular activities, such as growth, proliferation, and cell cycle progression. Perturbations in ribosomal biogenesis can initiate so-called nucleolar stress. The process through which ribosomal proteins (RPs) transduce nucleolar stress signals via MDM2 to p53 has been described as a crucial tumor-suppression mechanism. In this review we focus on recent progress pertaining to the function and mechanism of RPs in association with the MDM2–p53 tumor-suppression network, and the potential implications this surveillance network has for cancer development.
中文翻译:
RP-MDM2-p53途径:将核糖体生物发生与肿瘤监测联系起来。
核糖体生物发生与细胞活动紧密相关,例如生长,增殖和细胞周期进程。核糖体生物发生中的扰动会引发所谓的核仁压力。核糖体蛋白(RPs)通过MDM2传递核仁应激信号到p53的过程已被描述为一种重要的肿瘤抑制机制。在这篇综述中,我们重点关注与MDM2-p53肿瘤抑制网络相关的RPs功能和机制的最新进展,以及该监测网络对癌症发展的潜在影响。