Ribosomal biogenesis is tightly associated with cellular activities, such as growth, proliferation, and cell cycle progression. Perturbations in ribosomal biogenesis can initiate so-called nucleolar stress. The process through which ribosomal proteins (RPs) transduce nucleolar stress signals via MDM2 to p53 has been described as a crucial tumor-suppression mechanism. In this review we focus on recent progress pertaining to the function and mechanism of RPs in association with the MDM2–p53 tumor-suppression network, and the potential implications this surveillance network has for cancer development.

中文翻译：

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RP-MDM2-p53途径：将核糖体生物发生与肿瘤监测联系起来。

核糖体生物发生与细胞活动紧密相关，例如生长，增殖和细胞周期进程。核糖体生物发生中的扰动会引发所谓的核仁压力。核糖体蛋白（RPs）通过MDM2传递核仁应激信号到p53的过程已被描述为一种重要的肿瘤抑制机制。在这篇综述中，我们重点关注与MDM2-p53肿瘤抑制网络相关的RPs功能和机制的最新进展，以及该监测网络对癌症发展的潜在影响。