Migraine is a common neurovascular brain disorder with heterogeneous clinical presentation, including recurrent headache attacks. The pathophysiology of migraine is complex, and a number of genomic regions have been associated with the development of migraine. In this study, we analyzed the allele and genotype frequencies of the urotensin-II gene (UTS2) polymorphisms, Thr21Met and Ser89Asn, among Turkish patients with migraine. A total of 146 patients with migraine (14 with aura [MA group] and 132 without aura [MO group]) were genotyped for Thr21Met and Ser89Asn polymorphisms and compared with 154 age- and sex-matched healthy controls. The UTS2 gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). No significant differences were observed in allele and genotype frequencies for Thr21Met and Ser89Asn polymorphisms between the patients with migraine and control group. Similarly, we did not observe significant differences in allele and genotype frequencies between MA and MO and control group. Moreover, the haplotype analysis showed no association between UTS2 gene haplotypes (MN, MS, TN, and TS) and migraine. In summary, Thr21Met and Ser89Asn polymorphisms of the UTS2 gene are not risk factors for migraine in our sample of Turkish migraine patients.

中文翻译：

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尿紧张素II（UTS2）基因多态性（Thr21Met和Ser89Asn）与偏头痛之间缺乏关联。

偏头痛是一种常见的神经血管性脑部疾病，临床表现不一，包括反复发作的头痛发作。偏头痛的病理生理学很复杂，并且许多基因组区域与偏头痛的发展有关。在这项研究中，我们分析了土耳其偏头痛患者中尿紧张素II基因（UTS2）多态性Thr21Met和Ser89Asn的等位基因和基因型频率。对总共146例偏头痛患者（14例先兆[MA组]和132例无先兆[MO组]）进行了Thr21Met和Ser89Asn多态性的基因分型，并与154个年龄和性别相匹配的健康对照进行了比较。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析UTS2基因多态性。在偏头痛患者和对照组之间，Thr21Met和Ser89Asn多态性的等位基因和基因型频率无明显差异。同样，我们没有观察到MA和MO与对照组之间等位基因和基因型频率的显着差异。此外，单倍型分析显示UTS2基因单倍型（MN，MS，TN和TS）与偏头痛之间没有关联。总之，在我们的土耳其偏头痛患者样本中，UTS2基因的Thr21Met和Ser89Asn多态性不是偏头痛的危险因素。和TS）和偏头痛。总之，在我们的土耳其偏头痛患者样本中，UTS2基因的Thr21Met和Ser89Asn多态性不是偏头痛的危险因素。和TS）和偏头痛。总之，在我们的土耳其偏头痛患者样本中，UTS2基因的Thr21Met和Ser89Asn多态性不是偏头痛的危险因素。