Objective: The objective of this paper was to link the phytochemical and metabolic research treating quinolinic acid induced oxidative stress in neurodegenerative disorders.

Methods: Quinolinic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, plays a role in the oxidative stress associated with many neurological disorders and is used to simulate disorders such as Parkinson’s disease.

Results: In these models, phytochemicals have been shown to reduce striatal lesion size, reduce inflammation and prevent lipid peroxidation caused by quinolinic acid.

Conclusion: These results suggest that phenolic compounds, a class of phytochemicals, including flavonoids and diarylheptanoids, should be further studied to develop new treatments for oxidative stress related neurological disorders.

目的：本文的目的是将喹啉酸诱导的神经退行性疾病的氧化应激的植物化学和代谢研究联系起来。

方法：喹啉酸是色氨酸分解代谢的犬尿氨酸途径的代谢产物，在与许多神经系统疾病有关的氧化应激中起作用，并用于模拟帕金森氏病等疾病。

结果：在这些模型中，已显示出植物化学物质可减少纹状体病变大小，减少炎症并防止喹啉酸引起的脂质过氧化。

结论：这些结果表明，应进一步研究酚类化合物（一类植物化学物质，包括类黄酮和二芳基庚烷类），以开发出与氧化应激相关的神经系统疾病的新疗法。