BACKGROUND Two open-controlled studies evaluated the tolerance and the efficacy of a 10 mg/mL deltamethrin-based pour-on solution (Deltanil®; Virbac, France) in treating (study 1) and preventing (study 2) natural Damalinia equi infestations in horses. In study 1, seven adult horses received 10 mL of the solution from mane to tail head on day 0 (D0). Four adult horses, living separately, served as non-treated controls. All were naturally infected. Lice burden was recorded by counting the number of live parasites, bilaterally, over seven anatomic regions. Lesional score was based on alopecia, crusts, papules/pustules, nodules/plaques, scales and wounds, each assessed on a 0-3 scale. Evaluation was performed on D0 and subsequently weekly until D56 in treated horses and on D0 and D56 in control horses. In study 2, six adult horses free of parasites were similarly treated on D-2 and D30. Two adult horses, naturally infested with D. equi and left untreated, were mixed with the treated horses from D0 to D60. Evaluation was performed similarly to study 1 on all horses, fortnightly until D60. RESULTS No adverse event was recorded in either study. In study 1, parasite and lesional scores of control horses were maintained on D56. Parasite scores of the treated horses were reduced by 98% on D7 and 100% from D15 to D56 (mean [SD]: D0 44 [58.4]). Lesional score in treated horses was reduced by 24, 82, 47, 91, 96, 93, 93 and 100% on D7, 15, 21, 28, 35, 42, 50 and 56, respectively (mean [SD]: D0 3.1 [1.8]). In study 2, the lice populations remained high in the two control horses throughout the study (max mean [SD]: D0 159 [151.3], min D45 34 [39.6]). On treated animals, all parasite counts were negative except on D15 (one louse found). The protection rate was 99.7% on D15 and 100% from D30 to D60. CONCLUSIONS A single application of the 10 mg/mL deltamethrin preparation was effective and safe in the treatment and in the prevention of lice infestation in these horses. It was also effective in preventing new infestations for one month.

中文翻译：

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使用10 mg / mL溴氰菊酯局部施用控制马虱侵扰。

背景两项开放式对照研究评估了基于溴氰菊酯的10 mg / mL泼洒溶液（Deltanil®； Virbac，法国）在治疗（研究1）和预防（研究2）天然的达马莉亚虫等量侵染中的耐受性和功效。马匹。在研究1中，七只成年马在第0天（D0）从鬃毛到尾巴接受了10 mL溶液。四只成年马分别生活，作为未治疗的对照。所有这些都是自然感染的。通过在七个解剖区域中双边计数活寄生虫的数量来记录虱子的负担。病变评分基于脱发，结rust，丘疹/脓疱，结节/斑块，鳞屑和伤口，均以0-3评分进行评估。在治疗后的马中对D0进行评估，随后每周进行一次，直至D56，而在对照马中对D0和D56进行评估。在研究2中，在D-2和D30上类似地处理了六只没有寄生虫的成年马。将两只自然受马鞭毛虫侵染且未经治疗的成年马与从D0到D60的已治疗马混合。对每匹马进行与研究1相似的评估，每两周一次直到D60。结果两项研究均未记录不良事件。在研究1中，对照马的寄生虫和病斑得分在D56上得以维持。经治疗的马的寄生虫评分在D7降低了98％，从D15降低到D56降低了100％（平均[SD]：D0 44 [58.4]）。在D7、15、21、28、35、42、50和56上，接受治疗的马的损伤评分分别降低了24％，82％，47％，91％，96％，93％，93％和100％（平均值[SD]：D0 3.1 [1.8]）。在研究2中，在整个研究中，两匹对照马的虱子种群数量仍然很高（最大平均[SD]：D0 159 [151.3]，最小D45 34 [39.6]）。在治疗的动物上，除D15外（发现一只虱子），所有寄生虫计数均为阴性。D15的保护率为99.7％，D30至D60的保护率为100％。结论单次使用10 mg / mL溴氰菊酯制剂可有效，安全地治疗和预防这些马的虱子侵扰。它也有效地防止了一个月的新病。