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Ovarian ecdysteroid biosynthesis and female germline stem cells.
FLY ( IF 2.4 ) Pub Date : 2017-02-21 , DOI: 10.1080/19336934.2017.1291472
Tomotsune Ameku 1 , Yuto Yoshinari 1 , Ruriko Fukuda 2 , Ryusuke Niwa 3, 4
Affiliation  

The germline stem cells (GSCs) are critical for gametogenesis throughout the adult life. Stem cell identity is maintained by local signals from a specialized microenvironment called the niche. However, it is unclear how systemic signals regulate stem cell activity in response to environmental cues. In our previous article, we reported that mating stimulates GSC proliferation in female Drosophila. The mating-induced GSC proliferation is mediated by ovarian ecdysteroids, whose biosynthesis is positively controlled by Sex peptide signaling. Here, we characterized the post-eclosion and post-mating expression pattern of the genes encoding the ecdysteroidogenic enzymes in the ovary. We further investigated the biosynthetic functions of the ovarian ecdysteroid in GSC maintenance in the mated females. We also briefly discuss the regulation of the ecdysteroidogenic enzyme-encoding genes and the subsequent ecdysteroid biosynthesis in the ovary of the adult Drosophila.



中文翻译:

卵巢蜕皮甾类生物合成和雌性生殖干细胞。

种系干细胞(GSC)对于整个成年生活中的配子发生至关重要。干细胞的身份是通过来自称为小生境的特殊微环境的局部信号来维持的。但是,尚不清楚系统信号如何响应环境提示调节干细胞活性。在我们之前的文章中,我们报道了交配刺激雌性果蝇中的GSC增殖。交配诱导的GSC增殖是由卵巢蜕皮类固醇介导的,其蜕皮激素的生物合成受到Sex肽信号传导的正向控制。在这里,我们表征了卵巢中编码蜕皮类固醇生成酶的基因的克隆后和交配后表达模式。我们进一步研究了卵巢蜕皮甾体在已交配雌性动物的GSC维持中的生物合成功能。我们还简要讨论了蜕皮激素生成酶编码基因的调控以及成年果蝇卵巢中蜕皮激素的生物合成。

更新日期:2017-02-21
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