BACKGROUND Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE). The aim of this study is to investigate the potential role of circulating sRAGE in osteoporosis, in particular evaluating the correlation of sRAGE with the fracture risk, in association with bone mineral density, the fracture risk marker FGF23, and lipid metabolism. RESULTS Circulating level of soluble RAGE correlate with osteopenia and osteoporosis level. Serum sRAGE resulted clearly associated on the one hand to bone fragility and, on the other hand, with BMI and leptin. sRAGE is particularly informative because serum sRAGE is able to provide, as a single marker, information about both the aspects of osteoporotic disease, represented by bone fragility and lipid metabolism. CONCLUSIONS The measure serum level of sRAGE could have a potential diagnostic role in the monitoring of osteoporosis progression, in particular in the evaluation of fracture risk, starting from the prevention and screening stage, to the osteopenic level to osteoporosis.

中文翻译：

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根据BMI，脂肪因子和骨折风险评估骨质疏松症中循环sRAGE：一项初步的观察性研究。

背景技术骨质疏松症是基于骨形成和骨吸收速率之间的年龄依赖性失衡的系统性代谢疾病。关于这种疾病的发病机理的最新研究表明，骨质疏松性骨脆性的基础上，骨骼重塑障碍可能与蛋白质糖基化以及氧化应激有关。糖基化反应导致糖基化终产物（AGEs）的产生，而糖基化终产物累积到骨骼中，并与AGE受体（RAGE）结合。这项研究的目的是研究循环sRAGE在骨质疏松症中的潜在作用，特别是评估sRAGE与骨折风险，骨矿物质密度，骨折风险标志物FGF23和脂质代谢的相关性。结果可溶性RAGE的循环水平与骨质减少和骨质疏松症水平相关。血清sRAGE一方面明显与骨骼脆弱性有关，另一方面与BMI和瘦素有关。sRAGE特别有用，因为血清sRAGE能够提供有关骨质疏松疾病两个方面的信息（以骨脆性和脂质代谢为代表），作为单一标记。结论血清sRAGE的水平可能在监测骨质疏松症的进展中具有潜在的诊断作用，特别是在从预防和筛查阶段到骨质疏松症至骨质疏松症的骨折风险评估中。sRAGE特别有用，因为血清sRAGE能够提供有关骨质疏松疾病两个方面的信息（以骨脆性和脂质代谢为代表），作为单一标记。结论血清sRAGE的水平可能在监测骨质疏松症的进展中具有潜在的诊断作用，特别是在从预防和筛查阶段到骨质疏松症至骨质疏松症的骨折风险评估中。sRAGE特别有用，因为血清sRAGE能够提供有关骨质疏松疾病两个方面的信息（以骨脆性和脂质代谢为代表），作为单一标记。结论血清sRAGE的水平可能在监测骨质疏松症的进展中具有潜在的诊断作用，特别是在从预防和筛查阶段到骨质疏松症至骨质疏松症的骨折风险评估中。