The virulence and pathogenicity of various types of Toxoplasma gondii differ considerably in mice. Recent studies have claimed that similar phenomenon was observed in humans, but no relevant studies have been performed to validate this finding. In addition, reports showing association between a given T. gondii type and outcomes of human infection yielded conflicting results. To provide a more precise estimation of the association and a more reliable conclusion on this subject, we performed this meta-analysis. Relevant literatures were identified in multiple databases and selected based on strict screening. T. gondii-type proportions among different severities of infection were calculated and compared using Fisher's exact test. Pooled odds ratios (OR) were calculated. Our results showed that the difference among T. gondii-type proportions was significant (p < 0.0001). In addition, significant associations were detected between Type I strains infection and congenital toxoplasmosis (OR: 1.91, p = 0.0009), Type III strains infection and pulmonary toxoplasmosis (OR: 5.15, p = 0.04). In our subgroup analysis, Type I strains were significantly associated with cerebral toxoplasmosis in offspring (OR: 1.81, p = 0.02). This result indicated that different types of T. gondii exhibited different virulence and caused different outcomes in humans.

中文翻译：

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弓形虫类型与人类感染结局之间的关联：一项荟萃分析。

各种类型的弓形虫在小鼠中的毒力和致病性差异很大。最近的研究声称在人类中观察到了类似的现象，但是还没有进行相关的研究来证实这一发现。另外，报告显示给定的弓形虫类型与人类感染的结果之间的关联产生了矛盾的结果。为了提供对该关联的更精确的估计以及对该主题的更可靠的结论，我们进行了这项荟萃分析。在多个数据库中确定了相关文献，并根据严格的筛选进行了选择。使用费舍尔精确检验计算并比较了不同严重程度之间的弓形虫型比例。计算合并的优势比（OR）。我们的结果表明T之间存在差异。冈底型比例显着（p <0.0001）。此外，在I型毒株感染与先天性弓形虫病之间（OR：1.91，p = 0.0009），III型毒株感染与肺部弓形虫病（OR：5.15，p = 0.04）之间存在显着关联。在我们的亚组分析中，I型菌株与后代的脑弓形虫病显着相关（OR：1.81，p = 0.02）。该结果表明，不同类型的弓形虫表现出不同的毒力并在人类中引起不同的结果。I型毒株与后代脑弓形虫病显着相关（OR：1.81，p = 0.02）。该结果表明，不同类型的弓形虫表现出不同的毒力并在人类中引起不同的结果。I型毒株与后代脑弓形虫病显着相关（OR：1.81，p = 0.02）。该结果表明，不同类型的弓形虫表现出不同的毒力并在人类中引起不同的结果。