According to experimental data, eukaryote unicellulars are able to learn, have immunity and memory. Learning is carried out in a very primitive form, and the memory is not neural but an epigenetic one. However, this epigenetic memory, which is well justified by the presence and manifestation of hormonal imprinting, is strong and permanent in the life of cell and also in its progenies. This memory is epigenetically executed by the alteration and fixation of methylation pattern of genes without changes in base sequences. The immunity of unicellulars is based on self/non-self discrimination, which leads to the destruction of non-self invaders and utilization of them as nourishment (by phagocytosis). The tools of learning, memory, and immunity of unicellulars are uniformly found in plasma membrane receptors, which formed under the effect of dynamic receptor pattern generation, suggested by Koch et al., and this is the basis of hormonal imprinting, by which the encounter between a chemical substance and the cell is specifically memorized. The receptors and imprinting are also used in the later steps of evolution up to mammals (including man) in each mentioned functions. This means that learning, memory, and immunity can be deduced to a unicellular eukaryote level.

中文翻译：

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单细胞真核生物上复杂的多细胞功能：学习，记忆和免疫。

根据实验数据，真核生物单细胞能够学习，具有免疫力和记忆力。学习是以非常原始的形式进行的，记忆不是神经的，而是表观遗传的。但是，这种表观遗传记忆在荷尔蒙印迹的存在和表现中得到了很好的证明，在细胞及其后代的生命中是强大而持久的。这种记忆是通过基因的甲基化模式的改变和固定在表观遗传上执行的，而不改变碱基序列。单细胞的免疫是基于自我/非自我的歧视，这会导致非自我入侵者的破坏，并将其作为营养物（通过吞噬作用）加以利用。在质膜受体中统一发现了单细胞学习，记忆和免疫的工具，它是由Koch等人提出的，在动态受体模式产生的作用下形成的，并且这是荷尔蒙印迹的基础，通过它可以特异性地记忆化学物质与细胞之间的相遇。在提到的每种功能中，受体和印迹也可用于进化到哺乳动物（包括人）的后期步骤中。这意味着可以将学习，记忆和免疫力推导出单细胞真核生物水平。