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Astroglial versus Neuronal D-Serine: Fact Checking
Trends in Neurosciences ( IF 14.6 ) Pub Date : 2017-09-01 , DOI: 10.1016/j.tins.2017.05.007
Thomas Papouin 1 , Christian Henneberger 2 , Dmitri A Rusakov 3 , Stéphane H R Oliet 4
Affiliation  

The activation of NMDA receptors (NMDARs) is conditioned by the binding of a co-agonist to a dedicated receptor binding site. It is now largely accepted that D-serine plays this role at many central synapses in the hippocampus, amygdala, hypothalamus, nucleus accumbens, and in prefrontal, visual, and somatosensory cortices. D-Serine has been found to be synthesized, stored, and released by astrocytes ( Figure 1 ). However, several immunolabeling studies and experiments in genetically modified animals have recently led to a suggestion that neurons are primarily responsible for the synthesis and release of D-serine [1] . Here we argue that such conclusions could have resulted from the erroneous interpretation of experimental data and that they are at odds with a substantial amount of published work.

中文翻译:

星形胶质细胞与神经元 D-丝氨酸:事实核查

NMDA 受体 (NMDAR) 的激活取决于共激动剂与专用受体结合位点的结合。现在人们普遍认为,D-丝氨酸在海马、杏仁核、下丘脑、伏隔核以及前额叶、视觉和体感皮层的许多中央突触中发挥着这种作用。已发现 D-丝氨酸由星形胶质细胞合成、储存和释放(图 1)。然而,最近在转基因动物中进行的几项免疫标记研究和实验表明,神经元主要负责 D-丝氨酸的合成和释放 [1]。在这里,我们认为这样的结论可能是由于对实验数据的错误解释造成的,并且它们与大量已发表的作品不一致。
更新日期:2017-09-01
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