The synthesis of microcapsules via in situ polymerization is a labor-intensive and time-consuming process, where many composition and process factors affect the microcapsule formation and its morphology. Herein, we report a novel combinatorial technique for the preparation of melamine-formaldehyde microcapsules, using a custom-made and automated high-throughput platform (HTP). After performing validation experiments for ensuring the accuracy and reproducibility of the novel platform, a design of experiment study was performed. The influence of different encapsulation parameters was investigated, such as the effect of the surfactant, surfactant type, surfactant concentration and core/shell ratio. As a result, this HTP-platform is suitable to be used for the synthesis of different types of microcapsules in an automated and controlled way, allowing the screening of different reaction parameters in a shorter time compared to the manual synthetic techniques.

中文翻译：

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用于合成三聚氰胺-甲醛微胶囊的高通量平台。

通过原位聚合合成微胶囊是一项劳动密集且耗时的过程，其中许多组成和工艺因素都会影响微胶囊的形成及其形态。在这里，我们报告了一种新型的组合技术，该技术使用定制的自动化高通量平台（HTP）来制备三聚氰胺-甲醛微胶囊。在执行验证实验以确保新型平台的准确性和可重复性之后，进行了实验研究的设计。研究了不同包封参数的影响，如表面活性剂，表面活性剂类型，表面活性剂浓度和核/壳比的影响。因此，这种HTP平台适合用于以自动化和受控的方式合成不同类型的微胶囊，