Diabetes is rapidly emerging as one of the biggest health concerns worldwide, with profound implications for disability, mortality, and costs. This suddenly escalating rate of diabetes correlates with global industrialization and the production of plastics, pesticides, synthetic fertilizers, electronic waste, and food additives that release endocrine-disrupting chemicals (EDCs) into the environment and the food chain. Emerging evidence indicates an association between exposure of EDCs and diabetes. In humans, these chemicals are also metabolized by the gut microbiota and thereby their toxicodynamics are altered. In this review we highlight studies that focus on the role of gut microbiota in EDC-induced hyperglycemia and dysregulated glucose homeostasis. We also discuss the translational implications of understanding EDC-microbiota interactions for the diagnosis and treatment of diabetes.

中文翻译：

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肠道微生物群、内分泌干扰化学物质和糖尿病流行病

糖尿病正迅速成为全球最大的健康问题之一，对残疾、死亡率和成本产生深远影响。这种突然上升的糖尿病发病率与全球工业化以及塑料、杀虫剂、合成肥料、电子垃圾和食品添加剂的生产有关，这些塑料、杀虫剂、合成肥料、电子垃圾和食品添加剂将内分泌干扰化学物质 (EDC) 释放到环境和食物链中。新出现的证据表明 EDC 暴露与糖尿病之间存在关联。在人类中，这些化学物质也会被肠道微生物群代谢，从而改变它们的毒理学。在这篇综述中，我们重点关注肠道微生物群在 EDC 诱导的高血糖和葡萄糖稳态失调中的作用的研究。