The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of their roles in global and local Ca2+ homeostasis and intracellular Ca2+ signaling in a wide variety of cell types and tissues. It is becoming clear that the spatiotemporal patterns of expression of the PMCAs and the fact that their abundances and relative expression levels vary from cell type to cell type both reflect and impact on their specific functions in these cells. Over recent years it has become increasingly apparent that these genes have potentially significant roles in human health and disease, with PMCAs1-4 being associated with cardiovascular diseases, deafness, autism, ataxia, adenoma, and malarial resistance. This review will bring together evidence of the variety of tissue-specific functions of PMCAs and will highlight the roles these genes play in regulating normal physiological functions and the considerable impact the genes have on human disease.

中文翻译：

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血浆膜钙ATP酶及其在人类疾病中的主要新作用。

质膜钙ATP酶（PMCA）的四种哺乳动物同工型的Ca 2+挤出功能已得到很好的建立。关于它们在各种细胞类型和组织中的全局和局部Ca2 +稳态以及细胞内Ca2 +信号传导中的作用的信息也越来越多。逐渐清楚的是，PMCA表达的时空模式以及它们的丰度和相对表达水平随细胞类型的不同而变化的事实，既反映并影响了它们在这些细胞中的特定功能。近年来，越来越明显的是这些基因在人类健康和疾病中具有潜在的重要作用，其中PMCAs1-4与心血管疾病，耳聋，自闭症，共济失调，腺瘤和疟疾抵抗有关。