Human papillomavirus (HPV) is a sexually transmitted virus responsible for the development of cervical cancer, anal cancer, head and throat cancers, as well as genital area warts. A major focus of current HPV research is on preventing the virus from entering a cell and transferring its genetic material to the nucleus, thus potentially preventing the development of cancer. Although the available HPV vaccines are extremely successful, approximately 15 additional cancer-causing HPVs have been identified that the vaccines do not protect against. Therefore, roughly 150,000 cancer cases will not be prevented annually with the current vaccines. Research efforts focused on the basic cell biology of HPV infection have a goal of identifying common infectious events that may lead to inexpensive vaccines or anti-virals to prevent infection by most, if not all, HPVs. In this review we attempt to summarize what is known regarding the process of HPV binding, entry, and intracellular trafficking.

中文翻译：

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HPV进入细胞。

人乳头瘤病毒（HPV）是一种性传播病毒，负责宫颈癌，肛门癌，头和喉癌以及生殖器疣的发展。当前HPV研究的主要重点是防止病毒进入细胞并将其遗传物质转移到细胞核，从而潜在地预防癌症的发展。尽管可用的HPV疫苗非常成功，但已鉴定出约15种其他无法预防癌症的致癌HPV。因此，用目前的疫苗每年将无法预防大约150,000例癌症病例。针对HPV感染的基本细胞生物学的研究工作的目标是确定常见的感染事件，这些事件可能导致廉价的疫苗或抗病毒药物预防大多数（如果不是全部）感染，HPV。在这篇综述中，我们试图总结关于HPV结合，进入和细胞内运输过程的已知信息。