Natural products bearing a triazaspirocyclic motif have received significant attention in recent years. These compounds, which feature three nitrogen atoms attached to one quaternary carbon forming a spirocyclic scaffold, exhibit a wide range of biological activity and have promising applications in materials as well as in drug discovery. In this review article, we will discuss triazaspirocycles in Nature, their biological activity, and applications. Methods for the synthesis of triazaspirocycles as well as the reactivity of triazaspirocyclic scaffolds will be reviewed.

中文翻译：

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Triazaspirocycles：的发生，合成和应用。

近年来，带有三氮杂双环基序的天然产物受到了极大的关注。这些化合物的特征是三个氮原子与一个季碳原子相连，形成一个螺环骨架，具有广泛的生物活性，在材料和药物开发中具有广阔的应用前景。在这篇综述文章中，我们将讨论自然界中的三氮杂环类化合物，其生物活性及其应用。将综述合成三氮杂环环的方法以及三氮杂环环骨架的反应性。