The aim of this study was to measure advanced glycation end products (AGEs) among participants maintained on antipsychotics using the AGE Reader and to compare them with controls from the general population. Participants maintained on antipsychotics for at least 6 months were recruited from the Psychiatry Department at Rumailah Hospital, Doha, Qatar. Healthy controls were recruited from the primary healthcare centers in Doha, Qatar. AGEs of a total of 86 participants (48 patients and 38 controls) were recorded. Among the group maintained on antipsychotics, women, smokers, and Arabs had significantly higher AGEs levels compared with men, nonsmokers, and non-Arabs, respectively (P<0.05). The levels of AGEs were higher among the group of patients maintained on antipsychotics in comparison to controls; however, the difference did not reach statistical significance. This is the first study to examine AGEs in patients maintained on antipsychotics. Our findings showed that such patients do not differ significantly from controls comparing AGEs levels. Future investigations might need to consider recruiting a larger sample size using a prospective design.

中文翻译：

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维持抗精神病药治疗的患者中晚期糖基化终产物。

这项研究的目的是使用AGE Reader测量使用抗精神病药治疗的参与者中晚期糖基化终末产物（AGEs），并将其与一般人群的对照进行比较。从卡塔尔多哈Rumailah医院精神病科招募了使用抗精神病药治疗至少6个月的参与者。从卡塔尔多哈的主要保健中心招募健康对照。记录了总共86位参与者（48位患者和38位对照）的AGEs。在维持抗精神病药物治疗的人群中，女性，吸烟者和阿拉伯人的AGEs水平分别高于男性，非吸烟者和非阿拉伯人（P <0.05）。与对照组相比，在接受抗精神病药治疗的患者组中，AGEs水平较高；然而，差异未达到统计学意义。这是第一项检查抗精神病药物患者的AGEs的研究。我们的研究结果表明，这些患者与比较AGEs水平的对照组没有显着差异。未来的调查可能需要考虑使用前瞻性设计来招募更大的样本量。