当前位置: X-MOL 学术Pediatr. Allergy Immunol. Pulmonol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Low Beta-Adrenergic Sweat Responses in Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator-Related Metabolic Syndrome Children.
Pediatric Allergy, Immunology, and Pulmonology ( IF 0.9 ) Pub Date : 2017-03-01 , DOI: 10.1089/ped.2016.0662
Danieli Barino Salinas 1 , Lucia Kang 1 , Colleen Azen 2 , Paul Quinton 3, 4
Affiliation  

β-adrenergically stimulated sweat secretion depends on the function of the cystic fibrosis transmembrane conductance regulator (CFTR) and discriminates between cystic fibrosis (CF) patients and healthy controls. Therefore, we sought to determine the feasibility, safety, and efficacy of assaying β-adrenergic sweating in children identified by CF newborn screening to help determine prognoses for individuals with CFTR-related metabolic syndrome (CRMS). Preschool age children with a positive newborn screening test for CF participated in this cross-sectional study. Sweat rates were measured by evaporimetery (cyberDERM, inc.) as transepidermal water losses (g H2O/m2/h) before and after selectively stimulating sweat glands either cholinergically or β-adrenergically. Net peak sweat responses assayed as evaporation rates were compared between CF and CRMS cohorts. After a pilot test in adults, children between 4 and 6 years of age were evaluated (CF, n = 16; CRMS, n = 10). The test protocol was well tolerated; electrocardiograms and vital signs were within normal range for all subjects. The mean evaporative sweat rates in both groups in response to cholinergic stimulation were similar (CF, 60.3 ± 23.8; CRMS, 57.7 ± 13.9; p = 0.72) as well as to β-adrenergic stimulation (CF, 1.1 ± 1.7; CRMS, 2.0 ± 2.0; p = 0.14). The β-adrenergic sweat test is safe and well tolerated by young children. However, the β-adrenergic sweat secretion rates as measured by evaporimetery did not discriminate between CF and CRMS cohorts.

中文翻译:

囊性纤维化和囊性纤维化跨膜电导调节器相关代谢综合征儿童的低 β-肾上腺素能汗液反应。

β-肾上腺素能刺激的汗液分泌取决于囊性纤维化跨膜电导调节剂 (CFTR) 的功能,并可区分囊性纤维化 (CF) 患者和健康对照。因此,我们试图确定通过 CF 新生儿筛查确定的儿童中检测 β-肾上腺素能出汗的可行性、安全性和有效性,以帮助确定 CFTR 相关代谢综合征 (CRMS) 患者的预后。新生儿 CF 筛查试验呈阳性的学龄前儿童参与了这项横断面研究。通过蒸发仪 (cyberDERM, inc.) 测量出汗率,作为胆碱能或 β-肾上腺素能选择性刺激汗腺之前和之后的经表皮水分损失 (g H2O/m2/h)。比较 CF 和 CRMS 队列之间的蒸发率时测定的净峰值汗液反应。在对成人进行试点测试后,对 4 至 6 岁的儿童进行了评估(CF,n = 16;CRMS,n = 10)。测试方案耐受性良好;所有受试者的心电图和生命体征均在正常范围内。两组对胆碱能刺激的平均蒸发出汗率相似(CF,60.3±23.8;CRMS,57.7±13.9;p = 0.72)以及 β-肾上腺素能刺激(CF,1.1±1.7;CRMS,2.0) ± 2.0;p = 0.14)。β-肾上腺素能汗液试验安全且幼儿耐受性良好。然而,通过蒸发仪测量的 β-肾上腺素能汗液分泌率并未区分 CF 和 CRMS 队列。CMS,n = 10)。测试方案耐受性良好;所有受试者的心电图和生命体征均在正常范围内。两组对胆碱能刺激的平均蒸发出汗率相似(CF,60.3±23.8;CRMS,57.7±13.9;p = 0.72)以及 β-肾上腺素能刺激(CF,1.1±1.7;CRMS,2.0) ± 2.0;p = 0.14)。β-肾上腺素能汗液试验安全且幼儿耐受性良好。然而,通过蒸发仪测量的 β-肾上腺素能汗液分泌率并未区分 CF 和 CRMS 队列。CMS,n = 10)。测试方案耐受性良好;所有受试者的心电图和生命体征均在正常范围内。两组对胆碱能刺激的平均蒸发出汗率相似(CF,60.3±23.8;CRMS,57.7±13.9;p = 0.72)以及 β-肾上腺素能刺激(CF,1.1±1.7;CRMS,2.0) ± 2.0;p = 0.14)。β-肾上腺素能汗液试验安全且幼儿耐受性良好。然而,通过蒸发仪测量的 β-肾上腺素能汗液分泌率并未区分 CF 和 CRMS 队列。72) 以及 β-肾上腺素能刺激 (CF, 1.1 ± 1.7; CRMS, 2.0 ± 2.0; p = 0.14)。β-肾上腺素能汗液试验安全且幼儿耐受性良好。然而,通过蒸发仪测量的 β-肾上腺素能汗液分泌率并未区分 CF 和 CRMS 队列。72) 以及 β-肾上腺素能刺激 (CF, 1.1 ± 1.7; CRMS, 2.0 ± 2.0; p = 0.14)。β-肾上腺素能汗液试验安全且幼儿耐受性良好。然而,通过蒸发仪测量的 β-肾上腺素能汗液分泌率并未区分 CF 和 CRMS 队列。
更新日期:2019-11-01
down
wechat
bug