Human studies of brain stimulation have demonstrated modulatory effects on the perception of pain. However, whether the primary somatosensory cortical activity is associated with antinociceptive responses remains unknown. Therefore, we examined the antinociceptive effects of neuronal activity evoked by optogenetic stimulation of primary somatosensory cortex. Optogenetic transgenic mice were subjected to continuous or pulse-train optogenetic stimulation of the primary somatosensory cortex at frequencies of 15, 30, and 40 Hz, during a tail clip test. Reaction time was measured using a digital high-speed video camera. Pulse-train optogenetic stimulation of primary somatosensory cortex showed a delayed pain response with respect to a tail clip, whereas no significant change in reaction time was observed with continuous stimulation. In response to the pulse-train stimulation, video monitoring and local field potential recording revealed associated paw movement and sensorimotor rhythms, respectively. Our results show that optogenetic stimulation of primary somatosensory cortex at beta and gamma frequencies blocks transmission of pain signals in tail clip test.

中文翻译：

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尾夹试验中初级躯体感觉皮层的脉冲训练刺激阻滞疼痛知觉。

人类对脑刺激的研究已证明对疼痛的感知具有调节作用。然而，主要的体感皮层活动是否与抗伤害感受性反应相关仍是未知的。因此，我们研究了由原代体感皮层的光遗传学刺激引起的神经元活性的抗伤害感受作用。在尾夹测试期间，对光遗传学转基因小鼠以15、30和40 Hz的频率对初级体感皮层进行连续或脉冲序列光遗传学刺激。反应时间是使用数字高速摄像机测量的。初级躯体感觉皮层的脉冲序列光遗传学刺激显示相对于尾夹延迟的疼痛反应，而连续刺激未观察到反应时间的显着变化。响应于脉冲串刺激，视频监控和局部场电位记录分别显示了相关的爪子运动和感觉运动节律。我们的结果表明，在β和γ频率下光刺激原代体感皮层可阻止尾夹试验中疼痛信号的传递。