We investigated the relative efficacy and tolerability of aripiprazole once monthly (AOM) versus paliperidone palmitate (PP) for treating schizophrenia. Extensive databases searches on short-term, placebo-controlled, randomized studies of AOM and PP were performed. Indirect treatment comparisons were performed between the two long-acting injectable antipsychotics (LAIAs). The primary efficacy endpoint was the mean change in the Positive and Negative Syndrome Scale total score from baseline between each LAIA and placebo. The effect sizes were mean differences and odds ratio (ORs) with 95% confidence intervals (CIs) for the primary efficacy endpoint and safety/tolerability between two LAIAs, respectively. Mean difference in the primary efficacy endpoint was significantly different, favouring AOM over PP (OR: -6.4; 95% CI: -11.402 to -1.358); sensitivity analyses and noninferiority test (AOM vs. PP) confirmed the primary results. The overall early dropout rate was not significantly different between AOM and PP (OR: 1.223; 95% CI: 0.737-2.03). However, there was a significant difference in the early dropout rate in terms of lack of efficacy favouring AOM over PP (OR: 0.394; 95% CI: 0.185-0.841). Within the context of the inherent limitations of the current analysis, our results may suggest that there may be relative advantages for AOM over PP in the short-term treatment of schizophrenia.

中文翻译：

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长效注射阿立哌唑与帕潘立酮棕榈酸酯在精神分裂症治疗中的比较：系统评价和间接治疗比较。

我们调查了阿立哌唑每月一次（AOM）与帕潘立酮棕榈酸酯（PP）治疗精神分裂症的相对疗效和耐受性。对AOM和PP的短期，安慰剂对照，随机研究进行了广泛的数据库搜索。在两种长效抗精神病药（LAIA）之间进行了间接治疗比较。主要疗效终点是每个LAIA和安慰剂之间阳性和阴性综合征量表总得分相对于基线的平均变化。效应大小分别是主要疗效终点和两个LAIA之间安全性/耐受性的均值差和比值比（OR），均具有95％的置信区间（CI）。主要疗效终点的平均差异显着不同，AOM优于PP（OR：-6.4； 95％CI：-11.402至-1.358）；敏感性分析和非劣效性测试（AOM与PP）证实了主要结果。AOM和PP之间的总体早期辍学率没有显着差异（OR：1.223； 95％CI：0.737-2.03）。但是，由于缺乏AOM优于PP的疗效，早期辍学率存在显着差异（OR：0.394； 95％CI：0.185-0.841）。在当前分析的固有局限性的背景下，我们的结果可能表明，在精神分裂症的短期治疗中，AOM优于PP可能具有相对优势。就缺乏AOM优于PP的疗效而言，早期辍学率存在显着差异（OR：0.394； 95％CI：0.185-0.841）。在当前分析的固有局限性范围内，我们的结果可能表明，在精神分裂症的短期治疗中，AOM优于PP可能具有相对优势。就缺乏AOM优于PP的疗效而言，早期辍学率存在显着差异（OR：0.394； 95％CI：0.185-0.841）。在当前分析的固有局限性范围内，我们的结果可能表明，在精神分裂症的短期治疗中，AOM优于PP可能具有相对优势。