Memory consolidation involves the process by which newly acquired information becomes stored in a long-lasting fashion. Evidence acquired over the past several decades, especially from studies using post-training drug administration, indicates that emotional arousal during the consolidation period influences and enhances the strength of the memory and that multiple different chemical signaling systems participate in this process. The mechanisms underlying the emotional influences on memory involve the release of stress hormones and activation of the basolateral amygdala, which work together to modulate memory consolidation. Moreover, work suggests that this amygdala-based memory modulation occurs with numerous types of learning and involves interactions with many different brain regions to alter consolidation. Additionally, studies suggest that emotional arousal and amygdala activity in particular influence synaptic plasticity and associated proteins in downstream brain regions. This review considers the historical understanding for memory modulation and cellular consolidation processes and examines several research areas currently using this foundational knowledge to develop therapeutic treatments.

中文翻译：

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学习和记忆的情绪调节：药理学意义。

内存合并涉及以持久方式存储新获取的信息的过程。在过去的几十年中，尤其是从使用训练后药物管理的研究中获得的证据表明，巩固期的情绪唤醒影响并增强了记忆的强度，并且多种不同的化学信号系统参与了这一过程。情绪对记忆的潜在影响机制涉及压力激素的释放和基底外侧杏仁核的激活，两者共同作用以调节记忆巩固。此外，工作表明这种基于杏仁核的记忆调节发生在多种学习类型中，并且涉及与许多不同大脑区域的相互作用以改变固结。此外，研究表明，情绪唤醒和杏仁核活动特别影响下游大脑区域的突触可塑性和相关蛋白。这篇综述考虑了对记忆调节和细胞整合过程的历史理解，并考察了目前使用该基础知识来开发治疗方法的几个研究领域。