Objective

The aim of the study was to evaluate a possible effect of atorvastatin on renal interleukins (ILs) and prostaglandin E2 (PGE2) in type 1 diabetic rats.

Methods

Thirty-two male rats from a local Wisterderived strain were included in this prospective study and were classified into four groups. Each group consisted of eight animals: Group 1, non-diabetic negative controls; Group 2, diabetic positive controls; Group 3, non-diabetic rats receiving atorvastatin for 4 weeks; and Group 4, diabetic rats receiving atorvastatin for 4 weeks. At the end of the designated period, the animals were sacrificed by cervical dislocation, and the kidneys were excised and homogenized to determine the level of IL-1β, IL-6, IL-10, and PGE2. The study duration was from June 2015 to May 2016 at Al-Ahlyya Amman University, Amman, Jordan.

Results

In the kidneys of rats with streptozotocin-induced diabets, the levels of cytokines IL-1β, IL-6, IL-10, and PGE2 were significantly elevated above those of the control group. This clearly showed a detrimental effect of diabetes on the kidney. Treatment of diabetic rats with atorvastatin caused a decrease in all evaluated cytokines to levels near control values.

Conclusion

Our data suggest that atorvastatin has the potential to protect or attenuate diabetes-induced renal injury. However, the possible protective effect of atorvastatin should be supported by clinical evidence.

中文翻译：

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阿托伐他汀对1型糖尿病大鼠肾脏中白介素和前列腺素E2的影响。

客观的

该研究的目的是评估阿托伐他汀对1型糖尿病大鼠肾脏白介素（ILs）和前列腺素E2（PGE2）的可能作用。

方法

来自该本地Wisterderived品系的32只雄性大鼠被包括在该前瞻性研究中，并且被分为四组。每组由八只动物组成：第一组，非糖尿病阴性对照；第二组，非糖尿病阴性对照。第2组，糖尿病阳性对照；第3组，非糖尿病大鼠接受阿托伐他汀治疗4周；第4组，糖尿病大鼠接受阿托伐他汀治疗4周。在指定时期结束时，通过颈脱位法处死动物，并切除肾脏并匀浆以确定IL-1β，IL-6，IL-10和PGE2的水平。研究时间为2015年6月至2016年5月，约旦安曼Al-Ahlyya安曼大学。

结果

在链脲佐菌素诱发的糖尿病大鼠的肾脏中，细胞因子IL-1β，IL-6，IL-10和PGE2的水平明显高于对照组。这清楚地表明了糖尿病对肾脏的有害作用。用阿托伐他汀治疗糖尿病大鼠使所有评估的细胞因子降低至接近对照值的水平。

结论

我们的数据表明，阿托伐他汀具有保护或减轻糖尿病引起的肾损伤的潜力。但是，阿托伐他汀可能的保护作用应得到临床证据的支持。