BACKGROUND Spatial normalization of brain images, a prerequisite for voxel based morphometry analysis, may account for the large variability of the volumetric data in medication overuse headache (MOH); possibly because this disease concerns patients differing on both sex and age, and hence with different brain size and shape. METHODS The present study aimed at providing a subject-based analysis of macrostructure using a native space volumes segmentation (Freesurfer), and microstructure using a region of interest (ROI: i.e. hippocampus) tractography approach in MOH patients. RESULTS The results show that MOH patients had decreased volumes of left hemisphere temporal gyri (temporal superior, fusiform) and occipital middle gyrus, together with an increased volume of the left inferior (temporal) lateral ventricle. The left temporal volume was negatively correlated with depression score and medication dependence parameters. Seed-based tractography of the hippocampus revealed a decreased number of reconstructed fibers passing through the left hippocampus. CONCLUSION To our knowledge, these alterations have not been described with methods involving brain normalization, and they indicate that left hemisphere temporal areas, including the hippocampus, may play a role in MOH pathophysiology. Trial registration number NCT00833209. Registered 29 January 2009.

中文翻译：

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药物过度使用性头痛的脑结构研究和海马体成像：天然空间分析。

背景技术脑图像的空间归一化是基于体素的形态分析的先决条件，可以解释药物过度使用性头痛（MOH）中体积数据的巨大差异。可能是因为该疾病涉及的患者在性别和年龄上都不同，因此大脑大小和形状也不同。方法本研究旨在为MOH患者提供使用自然空间体积分割（Freesurfer）进行宏观结构的主题分析，并使用感兴趣区域（ROI：海马）体检方法对微观结构进行基于主题的分析。结果结果表明，MOH患者的左半球颞回（颞上，梭状）和枕中回的体积减少，而左下（颞）侧心室的体积增加。左颞体积与抑郁评分和药物依赖参数负相关。基于种子的海马体层摄影术显示，穿过左海马体的重建纤维数量减少。结论据我们所知，尚未用涉及大脑正常化的方法描述这些改变，它们表明左半球颞部区域，包括海马，可能在MOH病理生理学中起作用。试用注册号NCT00833209。2009年1月29日注册。这些变化尚未用涉及大脑正常化的方法进行描述，它们表明包括海马在内的左半球颞区可能在MOH病理生理学中起作用。试用注册号NCT00833209。2009年1月29日注册。这些变化尚未用涉及大脑正常化的方法进行描述，它们表明包括海马在内的左半球颞区可能在MOH病理生理学中起作用。试用注册号NCT00833209。2009年1月29日注册。