Macrocyclic chemistry is one of the emerging research areas in the chemical science. Macrocyclic compounds continue to attract significant attention due to their numerous possible applications particularly in the areas like biology, catalysis and industry. This review article summarizes the developments and advances in synthesis and medicinal applications of macrocyclic compounds derived from (benz)imidazole- and indole-based heterocycles. Important medicinal applications of (benz)imidazole- and indole-based macrocycles include antimicrobial and anticancer activities. The representative lead compounds in each series of macromolecules have been discussed. All these initial lead breakthroughs help validate the great potential of (benz)imidazole- and indole-based macrocyclic compounds as a class of effective medicinal agents.

中文翻译：

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（苯并咪唑基和吲哚基大环化合物的药物应用）。

大环化学是化学科学中新兴的研究领域之一。大环化合物由于其众多的可能应用而继续引起人们的极大关注，特别是在生物学，催化和工业领域。这篇综述文章总结了衍生自（苯）咪唑和吲哚基杂环的大环化合物的合成和医学应用的发展和进展。基于（苯并咪唑）和吲哚的大环化合物的重要医学应用包括抗微生物和抗癌活性。已经讨论了每个大分子系列中的代表性先导化合物。所有这些最初的铅突破都有助于验证基于（苯并咪唑）和吲哚的大环化合物作为一类有效药物的巨大潜力。