BACKGROUND Plants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun. Markhamia tomentosa (Benth.) K. Schum. (Bignoniaceae) is used as an antimalarial, anti-inflammatory, analgesic, antioxidant and anti-Alzheimer agent. The current study was undertaken in order to investigate its anti-amnesic and antioxidant potential on scopolamine-induced cognitive impairment and to determine its possible mechanism of action. METHODS Rats were pretreated with the aqueous extract (50 and 200 mg/kg, p.o.), for 10 days, and received a single injection of scopolamine (0.7 mg/kg, i.p.) before training in Y-maze and radial arm-maze tests. The biochemical parameters in the rat hippocampus were also assessed to explore oxidative status. Statistical analyses were performed using two-way ANOVA followed by Tukey's post hoc test. F values for which p < 0.05 were regarded as statistically significant. RESULTS In the scopolamine-treated rats, the aqueous extract improved memory in behavioral tests and decreased the oxidative stress in the rat hippocampus. Also, the aqueous extract exhibited anti-acetylcholinesterase activity. CONCLUSIONS These results suggest that the aqueous extract ameliorates scopolamine-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.

中文翻译：

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Markhamia tomentosa (Benth.) K. Schum 水提取物的认知增强和抗氧化活性。东莨菪碱大鼠模型中的茎皮。


背景技术马卡米亚属植物传统上被包括喀麦隆在内的西非国家不同地区的不同部落使用。 Markhamia tomentosa (Benth.) K. Schum。 （紫葳科）用作抗疟、抗炎、镇痛、抗氧化剂和抗阿尔茨海默病剂。目前的研究旨在研究其对东莨菪碱引起的认知障碍的抗遗忘和抗氧化潜力，并确定其可能的作用机制。方法 大鼠用水提取物（50 和 200 mg/kg，口服）预处理 10 天，并在 Y 迷宫和径向臂迷宫测试训练前单次注射东莨菪碱（0.7 mg/kg，腹腔注射） 。还评估了大鼠海马体的生化参数以探索氧化状态。使用双向方差分析和 Tukey 事后检验进行统计分析。 p < 0.05 的 F 值被认为具有统计显着性。结果 在接受东莨菪碱治疗的大鼠中，水提取物改善了行为测试中的记忆力，并降低了大鼠海马体的氧化应激。此外，水提取物还表现出抗乙酰胆碱酯酶活性。结论这些结果表明，水提取物通过减弱大鼠海马的氧化应激来改善东莨菪碱诱导的空间记忆障碍。