Aim of our study was to assess functional outcome measured by modified Rankin scale (mRS) in patients that were treated with thrombolytic therapy-recombinant tissue plasminogen activator (rtPA) after acute ischemic stroke. The study included 100 participants that were treated after acute ischemic stroke. Analyzed parameters included: gender; age groups: age 54 and below (Group_{up to-54}), 55-64 (Group_55-64), 65-74 (Group_65-74), and 75 and above (Group_75-up); cerebral blood flow (CBF) and cerebral blood volume (CBV). Considering time of rtPA administration, we analyzed 3 groups: between 1-2 hours from stroke onset (Time_1-2h), 2-3 hours (Time_2-3h) and 3-4.5 hours (Time_3h-up). NIHSS scores were analyzed: NIHSS 1-at admission and NIHSS 2-at discharge from hospital; and mRS values: RANKIN 1-at admission and RANKIN 2-at discharge from hospital. There is significant reduction in NIHSS and mRS scores between two measurements for all groups of evaluated parameters. CBF, CBV and NIHSS values at admission significantly correlated with mRS scores at admission (p<0.01), as well as with mRS scores at discharge except for CBF where statistical significance was (p=0.019). Significantly lower values of NIHSS at admission (p<0.01), CBF values (p<0.01) and CBV values (p<0.01) are noticed in the group with mRS≤2. Early induction of rtPA treatment in patients with acute ischemic stroke within first 4.5 hours significantly increases positive treatment outcome in both genders and for all evaluated age groups. Favorable outcome (mRS≤2) at the time of discharge from hospital is significantly associated with lower NIHSS values at admission.

中文翻译：

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通过改良的Rankin量表对rtPA治疗的急性缺血性卒中患者的功能结局进行评估。

我们研究的目的是评估在急性缺血性卒中后接受溶栓治疗-重组组织纤溶酶原激活剂（rtPA）治疗的患者中，以改良的Rankin量表（mRS）评估的功能结局。该研究包括100名在急性缺血性中风后接受治疗的参与者。分析的参数包括：性别；性别；性别。年龄组：54年龄和下方（集团_高达-54），55-64（集团_55-64），65-74（集团_65-74），以及75和上述（组_75向上）; 脑血流量（CBF）和脑血容量（CBV）。考虑到rtPA给药的时间，我们分析了3组：中风发作后1-2小时（时间_1-2h），2-3小时（时间_2-3h）和3-4.5小时（时间_{3h-up）之间}）。分析NIHSS得分：入院时为NIHSS 1，出院时为NIHSS 2；和mRS值：入院时为RANKIN 1，出院时为RANKIN 2。对于所有评估参数组，两次测量之间的NIHSS和mRS得分显着降低。入院时的CBF，CBV和NIHSS值与入院时的mRS得分显着相关（p <0.01），出院时与出院时的mRS得分显着相关，但CBF的统计显着性为（p = 0.019）。在mRS≤2的组中，入院时NIHSS的值（p <0.01），CBF值（p <0.01）和CBV值（p <0.01）明显较低。急性缺血性脑卒中的患者在头4.5小时内尽早诱导rtPA治疗，无论是性别还是所有评估年龄组，均显着提高了阳性治疗结果。